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Substance Name: Neridronic acid [INN]
RN: 79778-41-9
UNII: 8U27U3RIN4
InChIKey: PUUSSSIBPPTKTP-UHFFFAOYSA-N

Note

  • Used for therapy of Paget's disease of bone & malignant hypercalcaemia.

Molecular Formula

  • C6-H17-N-O7-P2

Molecular Weight

  • 277.1483
 
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Names and Synonyms

Name of Substance

  • 6-Amino-1-hydroxyhexane-1,1-diphosphonate
  • Neridronic acid [INN]

Synonyms

  • Acide neridronique
  • Acide neridronique [INN-French]
  • Acido neridronico
  • Acido neridronico [INN-Spanish]
  • Acidum neridronicum
  • Acidum neridronicum [INN-Latin]
  • Neridronate
  • Neridronic acid
  • Nerixia
  • UNII-8U27U3RIN4

Systematic Names

  • (6-Amino-1-hydroxyhexylidene)diphosphonic acid
  • Phosphonic acid, (6-amino-1-hydroxyhexylidene)bis-

Registry Numbers

CAS Registry Number

  • 79778-41-9

FDA UNII

  • 8U27U3RIN4

System Generated Number

  • 0079778419

Structure Descriptors

InChI

1S/C6H17NO7P2/c7-5-3-1-2-4-6(8,15(9,10)11)16(12,13)14/h8H,1-5,7H2,(H2,9,10,11)(H2,12,13,14)

InChIKey

PUUSSSIBPPTKTP-UHFFFAOYSA-N

Smiles

C(CCC(O)(P(=O)(O)O)P(=O)(O)O)CCN

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 650mg/kg (650mg/kg)   British UK Patent Application. Vol. #2096889,
mouse LD50 intravenous 85mg/kg (85mg/kg)   British UK Patent Application. Vol. #2096889,
mouse LD50 oral > 2gm/kg (2000mg/kg)   British UK Patent Application. Vol. #2096889,