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Substance Name: Enflurane [USAN:USP:INN:BAN:JAN]
RN: 13838-16-9
UNII: 91I69L5AY5
InChIKey: JPGQOUSTVILISH-UHFFFAOYSA-N
Note
- An extremely stable inhalation anesthetic that allows rapid adjustments of anesthesia depth with little change in pulse or respiratory rate.
Molecular Formula
- C3-H2-Cl-F5-O
Molecular Weight
- 184.4908
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
Classification Codes
- Anesthetic (Inhalation)
- Anesthetics
- Anesthetics, General
- Anesthetics, Inhalation
- Central Nervous System Agents
- Central Nervous System Depressants
- Drug / Therapeutic Agent
- Human Data
- Mutation Data
- Reproductive Effect
- Skin / Eye Irritant
- Tumor Data
Superlist Classification Code
- TWA (75 ppm); Not classifiable as a human carcinogen
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Names and Synonyms
Name of Substance
- Enflurane
- Enflurane [USAN:USP:INN:BAN:JAN]
MeSH Heading
- Enflurane
Synonyms
- (+-)-2-Chloro-1,1,2-trifluoroethyl difluoromethyl ether
- 2-Chloro-1,1,2-trifluoroethyl difluoromethyl ether
- 2-Chloro-1-(difluoromethoxy)-1,1,2-trifluoroethane
- Anesthetic 347
- Anesthetic Compound No. 347
- BRN 1903921
- C 347
- Compound 347
- Efrane
- EINECS 237-553-4
- Enflurane
- Enflurano
- Enflurano [INN-Spanish]
- Enfluranum
- Enfluranum [INN-Latin]
- Ethane, 2-chloro-1-(difluoromethoxy)-1,1,2-trifluoro-
- Ethane, 2-chloro-1-(difluoromethoxy)-1,1,2-trifluoro-, (+-)-
- Ethrane
- HSDB 7909
- Methylflurether
- NSC-115944
- OHIO 347
- UNII-91I69L5AY5
Systematic Names
- Enflurane
- Ethane, 2-chloro-1-(difluoromethoxy)-1,1,2-trifluoro-
- Ether, 2-chloro-1,1,2-trifluoroethyl difluoromethyl
Superlist Names
- Enflurane
- Enflurane [Anaesthetics, volatile]
Registry Numbers
CAS Registry Number
- 13838-16-9
FDA UNII
- 91I69L5AY5
System Generated Number
- 0013838169
Structure Descriptors
InChI
InChI=1S/C3H2ClF5O/c4-1(5)3(8,9)10-2(6)7/h1-2HInChIKey
JPGQOUSTVILISH-UHFFFAOYSA-NSmiles
FC(F)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
human | TCLo | inhalation | 1pph/6H (10000ppm) | KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED | Anesthesiology. Vol. 45, Pg. 557, 1976. |
mouse | LC50 | inhalation | 8100ppm/3H (8100ppm) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 12, Pg. 668, 1981. | |
mouse | LD50 | intraperitoneal | 3900uL/kg (3.9mL/kg) | LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Yakkyoku. Pharmacy. Vol. 32, Pg. 491, 1981. |
mouse | LD50 | oral | 5mL/kg (5mL/kg) | LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Yakkyoku. Pharmacy. Vol. 32, Pg. 491, 1981. |
mouse | LD50 | subcutaneous | 38800uL/kg (38.8mL/kg) | LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Yakkyoku. Pharmacy. Vol. 32, Pg. 491, 1981. |
rat | LC50 | inhalation | 14000ppm/3H (14000ppm) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 12, Pg. 668, 1981. | |
rat | LD50 | intraperitoneal | 6mL/kg (6mL/kg) | LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Yakkyoku. Pharmacy. Vol. 32, Pg. 491, 1981. |
rat | LD50 | oral | 5450uL/kg (5.45mL/kg) | LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA | Yakkyoku. Pharmacy. Vol. 32, Pg. 491, 1981. |
rat | LD50 | subcutaneous | 19500uL/kg (19.5mL/kg) | LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Yakkyoku. Pharmacy. Vol. 32, Pg. 491, 1981. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Boiling Point | 56.5 | deg C | EXP | |
log P (octanol-water) | 2.1 | (none) | EXP | |
Water Solubility | 5620 | mg/L | 37 | EXP |
Vapor Pressure | 591 | mm Hg | 25 | EST |
Henry's Law Constant | 0.013 | atm-m3/mole | 25 | EST |
Atmospheric OH Rate Constant | 1.19E-14 | cm3/molecule-sec | 25 | EXP |
Physical property data is provided to ChemIDplus by SRC, Inc.