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Substance Name: Ketanserin [USAN:INN:BAN]
RN: 74050-98-9
UNII: 97F9DE4CT4
InChIKey: FPCCSQOGAWCVBH-UHFFFAOYSA-N

Note

  • A selective serotonin receptor antagonist with weak adrenergic receptor blocking properties. The drug is effective in lowering blood pressure in essential hypertension. It also inhibits platelet aggregation. It is well tolerated and is particularly effective in older patients.

Molecular Formula

  • C22-H22-F-N3-O3

Molecular Weight

  • 395.4318
 

Classification Codes

  • Antihypertensive Agents
  • Cardiovascular Agents
  • Hematologic Agents
  • Neurotransmitter Agents
  • Platelet Aggregation Inhibitors
  • Serotonin Agents
  • Serotonin Antagonist
  • Serotonin Antagonists
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Names and Synonyms

Name of Substance

  • Ketanserin
  • Ketanserin [USAN:INN:BAN]

MeSH Heading

  • Ketanserin

Synonyms

  • 2,4(1H,3H)-Quinazolinedione, 3-(2-(4-(4-fluorobenzoyl)-1-piperidinyl)ethyl)-
  • 3-(2-(4-(p-Fluorobenzoyl)piperidino)ethyl)-2,4-(1H,3H)-quinazolinedione
  • EINECS 277-680-2
  • Ketanserin
  • Ketanserina
  • Ketanserina [INN-Spanish]
  • Ketanserine
  • Ketanserine [INN-French]
  • Ketanserinum
  • Ketanserinum [INN-Latin]
  • Ketaserin
  • R 41,468
  • R-41,468
  • UNII-97F9DE4CT4

Systematic Names

  • 2,4(1H,3H)-Quinazolinedione, 3-(2-(4-(4-fluorobenzoyl)-1-piperidinyl)ethyl)-
  • Ketanserin

Registry Numbers

CAS Registry Number

  • 74050-98-9

FDA UNII

  • 97F9DE4CT4

System Generated Number

  • 0074050989

Structure Descriptors

InChI

InChI=1S/C22H22FN3O3/c23-17-7-5-15(6-8-17)20(27)16-9-11-25(12-10-16)13-14-26-21(28)18-3-1-2-4-19(18)24-22(26)29/h1-8,16H,9-14H2,(H,24,29)

InChIKey

FPCCSQOGAWCVBH-UHFFFAOYSA-N

Smiles

Fc1ccc(cc1)C(=O)C2CCN(CCN3C(=O)Nc4ccccc4C3=O)CC2

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 231 deg C   EXP
log P (octanol-water) 3.29 (none)   EXP
Water Solubility 10 mg/L 25 EXP
Vapor Pressure 1.17E-13 mm Hg 25 EST
Henry's Law Constant 1.24E-17 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.56E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.