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Substance Name: Bicalutamide [USAN:USP:INN:BAN]
RN: 90357-06-5
UNII: A0Z3NAU9DP
InChIKey: LKJPYSCBVHEWIU-UHFFFAOYSA-N
Note
- Approved for treatment of advanced prostate cancer.
Molecular Formula
- C18-H14-F4-N2-O4-S
Molecular Weight
- 430.3766
Classification Codes
- Androgen Antagonists
- Antineoplastic
- Antineoplastic Agents
- Antiviral (COVID-19)
- Drug / Therapeutic Agent
- Hormone Antagonists
- Hormones, Hormone Substitutes, and Hormone Antagonists
- Reproductive Effect
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Names and Synonyms
Name of Substance
- Bicalutamide
- Bicalutamide [USAN:USP:INN:BAN]
Synonyms
- (+-)-4'-Cyano-alpha,alpha,alpha-trifluoro-3-((p-fluorophenyl)sulfonyl)-2-methyl-m-lactotoluidide
- Bicalutamide
- BRN 5364666
- Casodex
- CCRIS 8728
- HSDB 7655
- ICI 176,334
- ICI 176334
- UNII-A0Z3NAU9DP
Systematic Name
- Propanamide, N-(4-cyano-3-(trifluoromethyl)phenyl)-3-((4-fluorophenyl)sulfonyl)-2-hydroxy-2-methyl-, (+-)-
Registry Numbers
CAS Registry Number
- 90357-06-5
FDA UNII
- A0Z3NAU9DP
System Generated Number
- 0090357065
Structure Descriptors
InChI
InChI=1S/C18H14F4N2O4S/c1-17(26,10-29(27,28)14-6-3-12(19)4-7-14)16(25)24-13-5-2-11(9-23)15(8-13)18(20,21)22/h2-8,26H,10H2,1H3,(H,24,25)InChIKey
LKJPYSCBVHEWIU-UHFFFAOYSA-NSmiles
CC(O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
dog | LD | oral | > 2gm/kg (2000mg/kg) | Journal of Toxicological Sciences. Vol. 22, Pg. 75, 1997. | |
mouse | LD | oral | > 2gm/kg (2000mg/kg) | Journal of Toxicological Sciences. Vol. 22, Pg. 75, 1997. | |
mouse | LD50 | intraperitoneal | > 2gm/kg (2000mg/kg) | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 42, Pg. 197, 2000. | |
rabbit | LD50 | oral | > 200mg/kg (200mg/kg) | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 42, Pg. 197, 2000. | |
rat | LD | oral | > 2gm/kg (2000mg/kg) | Journal of Toxicological Sciences. Vol. 22, Pg. 75, 1997. | |
rat | LD50 | intraperitoneal | > 2gm/kg (2000mg/kg) | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 42, Pg. 197, 2000. |