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Substance Name: Clobetasol [INN:BAN]
RN: 25122-41-2
UNII: ADN79D536H
InChIKey: FCSHDIVRCWTZOX-DVTGEIKXSA-N
Note
- A derivative of PREDNISOLONE with high glucocorticoid activity and low mineralocorticoid activity. Absorbed through the skin faster than FLUOCINONIDE, it is used topically in treatment of PSORIASIS but may cause marked adrenocortical suppression.
Molecular Formula
- C22-H28-Cl-F-O4
Molecular Weight
- 410.9102
- All
- Classifications
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- Structure Descriptors
- Physical Properties
Classification Codes
- Adrenal Cortex Hormones
- Anti-Inflammatory Agents
- Glucocorticoids
- Hormones
- Hormones, Hormone Substitutes, and Hormone Antagonists
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Names and Synonyms
Name of Substance
- Clobetasol
- Clobetasol [INN:BAN]
MeSH Heading
- Clobetasol
Synonyms
- 21-Chloro-9-fluoro-11beta,17-dihydroxy-16beta-methylpregna-1,4-diene-3,20-dione
- Clobetasol
- Clobetasolum
- Clobetasolum [INN-Latin]
- EINECS 246-633-8
- HSDB 7994
- UNII-ADN79D536H
Systematic Names
- Clobetasol
- Pregna-1,4-diene-3,20-dione, 21-chloro-9-fluoro-11,17-dihydroxy-16-methyl-, (11beta,16beta)-
Registry Numbers
CAS Registry Number
- 25122-41-2
FDA UNII
- ADN79D536H
System Generated Number
- 0025122412
Structure Descriptors
InChI
InChI=1S/C22H28ClFO4/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,24)17(26)10-20(16,3)22(12,28)18(27)11-23/h6-7,9,12,15-17,26,28H,4-5,8,10-11H2,1-3H3/t12-,15-,16-,17-,19-,20-,21-,22-/m0/s1InChIKey
FCSHDIVRCWTZOX-DVTGEIKXSA-NSmiles
C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 195.5-197 | deg C | EXP | |
log P (octanol-water) | 2.48 | (none) | EXP | |
Water Solubility | 20 | mg/L | 25 | EST |
Vapor Pressure | 8.17E-13 | mm Hg | 25 | EST |
Henry's Law Constant | 1.62E-10 | atm-m3/mole | 25 | EST |
Atmospheric OH Rate Constant | 6.72E-11 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.