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Substance Name: Clobetasol [INN:BAN]
RN: 25122-41-2
UNII: ADN79D536H
InChIKey: FCSHDIVRCWTZOX-DVTGEIKXSA-N

Note

  • A derivative of PREDNISOLONE with high glucocorticoid activity and low mineralocorticoid activity. Absorbed through the skin faster than FLUOCINONIDE, it is used topically in treatment of PSORIASIS but may cause marked adrenocortical suppression.

Molecular Formula

  • C22-H28-Cl-F-O4

Molecular Weight

  • 410.9102
 

Classification Codes

  • Adrenal Cortex Hormones
  • Anti-Inflammatory Agents
  • Glucocorticoids
  • Hormones
  • Hormones, Hormone Substitutes, and Hormone Antagonists

Names and Synonyms

Name of Substance

  • Clobetasol
  • Clobetasol [INN:BAN]

MeSH Heading

  • Clobetasol

Synonyms

  • 21-Chloro-9-fluoro-11beta,17-dihydroxy-16beta-methylpregna-1,4-diene-3,20-dione
  • Clobetasol
  • Clobetasolum
  • Clobetasolum [INN-Latin]
  • EINECS 246-633-8
  • HSDB 7994
  • UNII-ADN79D536H

Systematic Names

  • Clobetasol
  • Pregna-1,4-diene-3,20-dione, 21-chloro-9-fluoro-11,17-dihydroxy-16-methyl-, (11beta,16beta)-

Registry Numbers

CAS Registry Number

  • 25122-41-2

FDA UNII

  • ADN79D536H

System Generated Number

  • 0025122412

Structure Descriptors

InChI

1S/C22H28ClFO4/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,24)17(26)10-20(16,3)22(12,28)18(27)11-23/h6-7,9,12,15-17,26,28H,4-5,8,10-11H2,1-3H3/t12-,15-,16-,17-,19-,20-,21-,22-/m0/s1

InChIKey

FCSHDIVRCWTZOX-DVTGEIKXSA-N

Smiles

C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)CCl)O)C)O)F)C

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 195.5-197 deg C   EXP
log P (octanol-water) 2.48 (none)   EXP
Water Solubility 20 mg/L 25 EST
Vapor Pressure 8.17E-13 mm Hg 25 EST
Henry's Law Constant 1.62E-10 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 6.72E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.