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Substance Name: Nortriptyline [INN:BAN]
RN: 72-69-5
UNII: BL03SY4LXB
InChIKey: PHVGLTMQBUFIQQ-UHFFFAOYSA-N
Note
- A metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia, and atypical depressions.
Molecular Formula
- C19-H21-N
Molecular Weight
- 263.3819
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Adrenergic Agents
- Adrenergic Uptake Inhibitors
- Antidepressive Agents
- Antidepressive Agents, Tricyclic
- Central Nervous System Agents
- Drug / Therapeutic Agent
- Membrane Transport Modulators
- Neurotransmitter Agents
- Neurotransmitter Uptake Inhibitors
- Psychotropic Drugs
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Names and Synonyms
Name of Substance
- Nortriptyline
- Nortriptyline [INN:BAN]
MeSH Heading
- Nortriptyline
Synonyms
- 10,11-Dihydro-5-(3-methylaminopropylidene)-5H-dibenzo(a,d)(1,4)cycloheptene
- 10,11-Dihydro-N-methyl-5H-dibenzo(a,d)cycloheptene-delta(5,gamma)-propylamine
- 3-(10,11-Dihydro-5H-dibenzo(a,d)cyclohepten-5-ylidene)-N-methylpropylamine
- 5-(3-(Methylamino)propylidene)dibenzo(a,e)cyclohepta(1,5)diene
- 5-(3-Methylaminopropylidene)-10,11-dihydro-5H-dibenzo(a,d)cycloheptene
- 5-(alpha-Methylaminopropylidene)dibenzo(a,d)cyclohepta(1,4)diene
- 5H-Dibenzo(a,d)cycloheptene-delta(sup 5),gamma-propylamine, 10,11-dihydro-N-methyl-
- Amitryptyline, demethyl-
- Ateben
- Avantyl
- Aventyl
- BRN 2216786
- CCRIS 9175
- Demethylamitriptyline
- Demethylamitryptyline
- Desitriptilina
- Desmethylamitriptyline
- EINECS 200-788-8
- HSDB 3371
- Lumbeck
- N-Methyl-3-(10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-yliden)propylamin
- Noramitriptyline
- Noritren
- Nortriptilina
- Nortriptilina [DCIT]
- Nortriptyline
- Nortriptylinum
- Nortriptylinum [INN-Latin]
- Nortryptiline
- Nortryptyline
- NSC 757234
- Sensaval
- UNII-BL03SY4LXB
Systematic Names
- 1-Propanamine, 3-(10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-ylidene)-N-methyl-
- 5H-Dibenzo(a,d)cycloheptene-delta(sup 5),gamma-propylamine, 10,11-dihydro-N-methyl-
- Nortriptyline
Registry Numbers
CAS Registry Number
- 72-69-5
FDA UNII
- BL03SY4LXB
System Generated Number
- 0000072695
Structure Descriptors
InChI
InChI=1S/C19H21N/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19/h2-5,7-11,20H,6,12-14H2,1H3InChIKey
PHVGLTMQBUFIQQ-UHFFFAOYSA-NSmiles
CNCCC=C1c2ccccc2CCc3ccccc13Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 70mg/kg (70mg/kg) | Journal of Medicinal Chemistry. Vol. 6, Pg. 338, 1963. | |
mouse | LD50 | intravenous | 17mg/kg (17mg/kg) | BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) | Journal of Medicinal Chemistry. Vol. 17, Pg. 65, 1974. |
mouse | LD50 | oral | 370mg/kg (370mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 1561, 1970. |
rat | LD50 | intravenous | 22mg/kg (22mg/kg) | BEHAVIORAL: ATAXIA BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) | Handbook of Experimental Pharmacology. Vol. 55, Pg. 527, 1980. |
rat | LD50 | oral | 502mg/kg (502mg/kg) | BEHAVIORAL: ATAXIA BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) | Handbook of Experimental Pharmacology. Vol. 55, Pg. 527, 1980. |
women | TDLo | oral | 160mg/kg (160mg/kg) | VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION BEHAVIORAL: COMA CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE | Journal of Toxicology, Clinical Toxicology. Vol. 37, Pg. 634, 1999. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
log P (octanol-water) | 4.740 | (none) | EST | |
Atmospheric OH Rate Constant | 1.74E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.