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Substance Name: Flunarizine hydrochloride [USAN:JAN]
RN: 30484-77-6
UNII: C11102TO53
InChIKey: RXKMOPXNWTYEHI-RDRKJGRWSA-N

Note

  • Flunarizine is a selective calcium entry blocker with calmodulin binding properties and histamine H1 blocking activity. It is effective in the prophylaxis of migraine, occlusive peripheral vascular disease, vertigo of central and peripheral origin, and as an adjuvant in the therapy of epilepsy.

Molecular Formula

  • C26-H26-F2-N2.2Cl-H

Molecular Weight

  • 477.4232
 

Classification Codes

  • Reproductive Effect
  • Vasodilator
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Names and Synonyms

Name of Substance

  • Flunarizine hydrochloride
  • Flunarizine hydrochloride [USAN:JAN]

Synonyms

  • (E)-1-(Bis(4-fluorophenyl)methyl)-4-(3-phenyl-2-propenyl)piperazine dihydrochloride
  • (E)-1-(Bis-(p-fluorophenyl)methyl)-4-cinnamylpiperazine dihydrochloride
  • EINECS 250-216-6
  • Flunarizine dihydrochloride
  • Flunarizine HCl
  • Flunarizine hydrochloride
  • KW-3149
  • NSC 757807
  • Piperazine, 1-(bis(4-fluorophenyl)methyl)-4-(3-phenyl-2-propenyl)-, dihydrochloride, (E)-
  • R 14,950
  • R 14950
  • UNII-C11102TO53

Systematic Names

  • (E)-1-(Bis(4-fluorophenyl)methyl)-4-cinnamylpiperazine dihydrochloride
  • Piperazine, 1-(bis(4-fluorophenyl)methyl)-4-(3-phenyl-2-propenyl)-, dihydrochloride, (E)-
  • Piperazine, 1-(bis(p-fluorophenyl)methyl)-4-cinnamyl-, dihydrochloride, (E)-

Registry Numbers

CAS Registry Number

  • 30484-77-6

FDA UNII

  • C11102TO53

Related Registry Number

  • 52468-60-7 (Parent)

System Generated Number

  • 0030484776

Molecular Formulas

Molecular Formula

  • C26-H26-F2-N2.2Cl-H

Molecular Formula Fragments

  • C26-H26-F2-N2
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

InChI=1S/C26H26F2N2.2ClH/c27-24-12-8-22(9-13-24)26(23-10-14-25(28)15-11-23)30-19-17-29(18-20-30)16-4-7-21-5-2-1-3-6-21;;/h1-15,26H,16-20H2;2*1H/b7-4+;;

InChIKey

RXKMOPXNWTYEHI-RDRKJGRWSA-N

Smiles

Cl.Cl.Fc1ccc(cc1)C(N2CCN(C\C=C\c3ccccc3)CC2)c4ccc(F)cc4

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral > 2gm/kg (2000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

GASTROINTESTINAL: NAUSEA OR VOMITING
Kiso to Rinsho. Clinical Report. Vol. 16, Pg. 1735, 1982.
mouse LD50 intraperitoneal 379mg/kg (379mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

LUNGS, THORAX, OR RESPIRATION: CYANOSIS
Kiso to Rinsho. Clinical Report. Vol. 16, Pg. 1735, 1982.
mouse LD50 intravenous 27mg/kg (27mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Kiso to Rinsho. Clinical Report. Vol. 16, Pg. 1735, 1982.
mouse LD50 oral 285mg/kg (285mg/kg)   European Patent Application. Vol. #0187639,
mouse LD50 subcutaneous > 2550mg/kg (2550mg/kg) BEHAVIORAL: ATAXIA

SKIN AND APPENDAGES (SKIN): HAIR: OTHER

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Kiso to Rinsho. Clinical Report. Vol. 16, Pg. 1735, 1982.
rat LD50 intraperitoneal 305mg/kg (305mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Kiso to Rinsho. Clinical Report. Vol. 16, Pg. 1735, 1982.
rat LD50 intravenous 35mg/kg (35mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Kiso to Rinsho. Clinical Report. Vol. 16, Pg. 1735, 1982.
rat LD50 oral 503mg/kg (503mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: ATAXIA
Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 1408, 1975.
rat LD50 subcutaneous 1793mg/kg (1793mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA
Kiso to Rinsho. Clinical Report. Vol. 16, Pg. 1735, 1982.