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Substance Name: Oxycodone hydrochloride [USAN:USP:JAN]
RN: 124-90-3
UNII: C1ENJ2TE6C
InChIKey: IGNAMRAQFUFUMH-KCTCKCTRSA-N

Note

  • Semisynthetic derivative of CODEINE that acts as a narcotic analgesic more potent and addicting than codeine.

Molecular Formula

  • C18-H21-N-O4.Cl-H

Molecular Weight

  • 337.801
 

Classification Codes

  • Analgesic (Narcotic)
  • Analgesics
  • Analgesics, Opioid
  • Central Nervous System Agents
  • Central Nervous System Depressants
  • Narcotics
  • Peripheral Nervous System Agents
  • Sensory System Agents
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Names and Synonyms

Name of Substance

  • Oxycodone hydrochloride [USAN:USP:JAN]

Synonyms

  • 14-Hydroxydihydrocodeinone hydrochloride
  • 4,5alpha-Epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one hydrochloride
  • Dihydrone hydrochloride
  • Dihydrooxycodeinone hydrochloride
  • Dihydroxycodeinone hydrochloride
  • Dinarkon
  • EINECS 204-717-1
  • Eubine
  • Eucodal
  • Eukodal
  • Eutagen
  • Oxaydo
  • Oxecta
  • Oxikon
  • Oxycodone HCl
  • Oxycodone hydrochloride
  • Oxycodone XR
  • Oxycon
  • Oxycontin
  • Oxygesic
  • Oxykodal
  • Oxykon
  • Oxynorm
  • Percodan hydrochloride
  • Remoxy
  • Rexista
  • Roxicodone
  • Stupenone
  • Tecodin
  • Tecodine
  • Tekodin
  • Thecodin
  • Thecodine
  • Thecodinum
  • Thekodin
  • UNII-C1ENJ2TE6C

Systematic Names

  • 4,5-Epoxy-14-hydroxy-3-methoxy-17-methyl-morphinan-6-one, hydrochloride, (5-alpha)-
  • Morphinan-6-one, 4,5-alpha-epoxy-14-hydroxy-3-methoxy-17-methyl-, hydrochloride
  • Morphinan-6-one, 4,5-epoxy-14-hydroxy-3-methoxy-17-methyl-, hydrochloride, (5alpha)-
  • Oxycodone hydrochloride

Mixture Names

  • Combunox
  • Percocet
  • Percodan
  • Percodan Demi
  • Tylox

Registry Numbers

CAS Registry Number

  • 124-90-3

FDA UNII

  • C1ENJ2TE6C

Related Registry Numbers

  • 25333-72-6 (Terephthalate)
  • 76-42-6 (Parent)

System Generated Number

  • 0000124903

Molecular Formulas

Molecular Formula

  • C18-H21-N-O4.Cl-H

Molecular Formula Fragments

  • C18-H21-N-O4
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

InChI=1S/C17H19NO4.ClH/c1-21-11-3-2-9-8-12-17(20)5-4-10(19)15-16(17,6-7-18-12)13(9)14(11)22-15;/h2-3,12,15,18,20H,4-8H2,1H3;1H/t12-,15+,16+,17-;/m1./s1

InChIKey

IGNAMRAQFUFUMH-KCTCKCTRSA-N

Smiles

Cl.COc1ccc2C[C@H]3NCC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo intravenous 2500ug/kg (2.5mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: ANALGESIA		 Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 194, Pg. 296, 1940.
frog LDLo subcutaneous 500mg/kg (500mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
mouse LDLo subcutaneous 350ug/kg (0.35mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: ANALGESIA		 Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 194, Pg. 296, 1940.
rabbit LDLo intravenous 45mg/kg (45mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
rabbit LDLo subcutaneous 80mg/kg (80mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) -0.15 (none)   EXP
Water Solubility 8110 mg/L 25 EST
Vapor Pressure 7.83E-16 mm Hg 25 EST
Henry's Law Constant 1.47E-23 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.77E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.