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Substance Name: Artemether [USAN:INN:BAN]
RN: 71963-77-4
UNII: C7D6T3H22J
InChIKey: SXYIRMFQILZOAM-HVNFFKDJSA-N
Note
- An artemisinin derivative that is used in the treatment of MALARIA.
Molecular Formula
- C16-H26-O5
Molecular Weight
- 298.376
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- Classifications
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- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Anthelmintics
- Anti-Infective Agents
- Antifungal Agents
- Antimalarial
- Antimalarials
- Antiparasitic Agents
- Antiplatyhelmintic Agents
- Antiprotozoal Agents
- Coccidiostats
- Reproductive Effect
- Schistosomicides
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Names and Synonyms
Name of Substance
- Artemether
- Artemether [USAN:INN:BAN]
MeSH Heading
- Artemether
Synonyms
- (3R,5aS,6R,8aS,9R,10S,12R,12aR)-Decahydro-10-methoxy-3,6,9-trimethyl-3,12-epoxy-12H-pyrano(4,3-j)-1,2-benzodioxepin
- Artemetero
- Artemetero [INN-Spanish]
- Artemether
- Artemetherum
- Artemetherum [INN-Latin]
- Artemisininelactol methyl ether
- beta-Artemether
- beta-Dihydroartemisinin methyl ether
- Dihydroartemisinin methyl ether
- Dihydroquinghaosu methyl ether
- HSDB 7456
- Methyl-dihydroartemisinine
- NSC 665970
- SM 224
- UNII-C7D6T3H22J
Systematic Names
- (3R,5aS,6R,8aS,9R,10S,12R,12aR)-Decahydro-10-methoxy-3,6,9-trimethyl-3,12-epoxy-12H-pyrano(4,3-j)-1,2-benzodioxepin
- 3,12-Epoxy-12H-pyrano(4,3-j)-1,2-benzodioxepin, decahydro-10-methoxy-3,6,9-trimethyl-, (3-alpha,5a-beta,6-beta,8a-beta,9-alpha,12-beta,12aR)-, (+)-
Mixture Name
- Coartem
Registry Numbers
CAS Registry Number
- 71963-77-4
FDA UNII
- C7D6T3H22J
Other Registry Number
- 159573-83-8
System Generated Number
- 0071963774
Structure Descriptors
InChI
InChI=1S/C16H26O5/c1-9-5-6-12-10(2)13(17-4)18-14-16(12)11(9)7-8-15(3,19-14)20-21-16/h9-14H,5-8H2,1-4H3/t9-,10-,11+,12+,13+,14-,15-,16-/m1/s1InChIKey
SXYIRMFQILZOAM-HVNFFKDJSA-NSmiles
CO[C@H]1O[C@@H]2O[C@@]3(C)Toxicity
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intramuscular | 263mg/kg (263mg/kg) | BEHAVIORAL: FOOD INTAKE (ANIMAL) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. Vol. 2, Pg. 138, 1981. |
| mouse | LD50 | oral | 1gm/kg (1000mg/kg) | Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. Vol. D13, Pg. 280, 1992. | |
| mouse | LD50 | subcutaneous | 390mg/kg (390mg/kg) | Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. Vol. D13, Pg. 280, 1992. |
Physical Properties
| Physical Property | Value | Units | Temp (deg C) | Source |
|---|---|---|---|---|
| log P (octanol-water) | 3.53 | (none) | EXP | |
| Water Solubility | 12.1 | mg/L | 25 | EST |
| Vapor Pressure | 4.02E-05 | mm Hg | 25 | EST |
| Henry's Law Constant | 1.88E-09 | atm-m3/mole | 25 | EST |
| Atmospheric OH Rate Constant | 4.05E-11 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.