Substance Name: Daclizumab [USAN:INN:BAN]
RN: 152923-56-3
UNII: CUJ2MVI71Y
Note
- An anti-TAC (INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT) humanized monoclonal antibody (immunoglobulin G1 disulfide with human-mouse monoclonal clone 1H4 light chain, dimer) that is used in the treatment of ACUTE RELAPSING MULTIPLE SCLEROSIS.
Molecular Formula
- Unspecified
Classification Codes
- Immunologic Factors
- Immunosuppressive Agents
- Monoclonal Antibody (Immunosuppressant)
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Names and Synonyms
Name of Substance
- Daclizumab
- Daclizumab [USAN:INN:BAN]
MeSH Heading
- Daclizumab
Synonyms
- Anti-TAC
- DAC HYP
- DAC-HYP
- Daclizumab
- Humanized anti-TAC monoclonal antibody comprised of four subunits, two heavy chains and two light chains. All four chains are linked via disulfide bridges. The molecule contains approximately 2% carbohydrate by weight. The antibody belongs to the IgG1 subclass. The DNA sequence is 90% human origin and 10% mouse origin. The humanized anti-TAC is directed to the TAC receptor or high-affinity interleukin 2 receptor. Immunoglobulin G 1 (human-mouse monoclonal clone 1H4 gamma-chain anti-human interleukin 2 receptor), disulfide with human-mouse monoclonal clone 1H4 light chain, dimer. Molecular weight is approximately 150,000 daltons
- Immunoglobulin G 1 (human-mouse monoclonal clone 1H4 gamma-chain anti-human interleukin 2 receptor), disulfide with human-mouse monoclonal clone 1H4 light chain, dimer
- NSC 725173
- Ro 24-7375
- UNII-CUJ2MVI71Y
- Zenapax
- Zinbryta
Systematic Name
- Immunoglobulin G 1 (human-mouse monoclonal clone 1H4 gamma-chain anti-human interleukin 2 receptor), disulfide with human-mouse monoclonal clone 1H4 light chain, dimer
Registry Numbers
CAS Registry Number
- 152923-56-3
FDA UNII
- CUJ2MVI71Y
System Generated Number
- 0152923563