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Substance Name: Methyprylon [USP:INN:BAN]
RN: 125-64-4
UNII: CUT48I42ON
InChIKey: SIDLZWOQUZRBRU-UHFFFAOYSA-N

Molecular Formula

  • C10-H17-N-O2

Molecular Weight

  • 183.249
 

Classification Codes

Classification Codes

  • Drug / Therapeutic Agent
  • Human Data

Superlist Classification Code

  • DEA Schedule III
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Names and Synonyms

Name of Substance

  • Methyprylon
  • Methyprylon [USP:INN:BAN]

Synonyms

  • 2,4-Dioxo-3,3-diethyl-5-methylpiperidine
  • 2,4-Dioxy-3,3-diethyl-5-methylpiperidine
  • 2,4-Piperidinedione, 3,3-diethyl-5-methyl-
  • 3,3-Diethyl-2,4-dioxo-5-methylpiperidine
  • 3,3-Diethyl-5-methyl-2,4-piperidinedione
  • 5-21-09-00615 (Beilstein Handbook Reference)
  • BRN 0082860
  • Dimerin
  • EINECS 204-745-4
  • HSDB 3128
  • Methyprylon
  • Methyprylone
  • Methyprylone [INN-French]
  • Methyprylonum
  • Methyprylonum [INN-Latin]
  • Metiprilon
  • Metiprilona
  • Metiprilona [INN-Spanish]
  • Metiprilone
  • Noctan
  • Noludar
  • NSC 30442
  • Ro 1-6463
  • UNII-CUT48I42ON

Systematic Names

  • 2,4-Piperidinedione, 3,3-diethyl-5-methyl-
  • Methyprylon

Superlist Names

  • DEA No. 2575
  • Methyprylon

Registry Numbers

CAS Registry Number

  • 125-64-4

FDA UNII

  • CUT48I42ON

System Generated Number

  • 0000125644

Structure Descriptors

InChI

InChI=1S/C10H17NO2/c1-4-10(5-2)8(12)7(3)6-11-9(10)13/h7H,4-6H2,1-3H3,(H,11,13)

InChIKey

SIDLZWOQUZRBRU-UHFFFAOYSA-N

Smiles

CCC1(CC)C(=O)NCC(C)C1=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LD50 oral 600mg/kg (600mg/kg)   Compilation of LD50 Values of New Drugs.
dog LD50 oral 300mg/kg (300mg/kg)   Compilation of LD50 Values of New Drugs.
guinea pig LDLo rectal 400mg/kg (400mg/kg)   Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 7, Pg. 513, 1960.
human TDLo oral 26mg/kg (26mg/kg) BEHAVIORAL: SLEEP Clinical Toxicology. Vol. 6, Pg. 563, 1973.
mouse LD50 intraperitoneal 530mg/kg (530mg/kg)   Strahlentherapie. Vol. 127, Pg. 245, 1965.
mouse LD50 intravenous 275mg/kg (275mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 264, 1972.
mouse LD50 oral 890mg/kg (890mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 118, Pg. 139, 1956.
rabbit LD50 intravenous 315mg/kg (315mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 264, 1972.
rabbit LD50 oral 520mg/kg (520mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 264, 1972.
rabbit LD50 subcutaneous 500mg/kg (500mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 264, 1972.
rat LD50 intravenous 380mg/kg (380mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 264, 1972.
rat LD50 oral 860mg/kg (860mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 264, 1972.
rat LD50 subcutaneous 400mg/kg (400mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 264, 1972.
women TDLo oral 600mg/kg (600mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: GENERAL ANESTHETIC		 JAMA, Journal of the American Medical Association. Vol. 198, Pg. 1213, 1966.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 0.78 (none)   EXP
Water Solubility 1.15E+04 mg/L 25 EST
Vapor Pressure 1.26E-05 mm Hg 25 EST
Henry's Law Constant 3.00E-11 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 3.04E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.