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Substance Name: Crotamiton [USP:INN:BAN:JAN]
RN: 483-63-6
UNII: D6S4O4XD0H
InChIKey: DNTGGZPQPQTDQF-XBXARRHUSA-N

Note

  • Antiscabies, antipruritic drug; active ingredient in Eurax Cream & Lotion (Geigy).

Molecular Formula

  • C13-H17-N-O

Molecular Weight

  • 203.283
 

Classification Codes

  • Agrochemicals
  • Drug / Therapeutic Agent
  • Pesticides
  • Scabicide
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Names and Synonyms

Name of Substance

  • Crotamiton
  • Crotamiton [USP:INN:BAN:JAN]

Synonyms

  • 3-12-00-01856 (Beilstein Handbook Reference)
  • AI3-17732
  • Bestloid
  • BRN 3275497
  • Caswell No. 431B
  • Crotalgin
  • Crotamitex
  • Crotamiton
  • Crotamitone
  • Crotamitonum
  • Crotamitonum [INN-Latin]
  • Crotan
  • Crotonyl-N-ethyl-o-toluidine
  • EINECS 207-596-3
  • EPA Pesticide Chemical Code 055701
  • Eurasil
  • Eurax
  • Euraxil
  • G 7857
  • N-Ethyl-N-(2-methylphenyl)-2-butenamide
  • N-Ethyl-o-crotonotoluidide
  • UNII-D6S4O4XD0H
  • Veteusan

Systematic Names

  • 2-Butenamide, N-ethyl-N-(2-methylphenyl)-
  • Crotamiton
  • N-Ethyl-o-crotonotoluidide
  • o-Crotonotoluidide, N-ethyl-

Registry Numbers

CAS Registry Number

  • 483-63-6

FDA UNII

  • D6S4O4XD0H

System Generated Number

  • 0000483636

Structure Descriptors

InChI

1S/C13H17NO/c1-4-8-13(15)14(5-2)12-10-7-6-9-11(12)3/h4,6-10H,5H2,1-3H3/b8-4+

InChIKey

DNTGGZPQPQTDQF-XBXARRHUSA-N

Smiles

c1(N(C(\C=C\C)=O)CC)c(cccc1)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 395mg/kg (395mg/kg)   Drugs in Japan Vol. 6, Pg. 233, 1982.
mouse LD50 oral 1600mg/kg (1600mg/kg)   "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 35, 1969.
mouse LD50 subcutaneous 1393mg/kg (1393mg/kg)   Drugs in Japan Vol. 6, Pg. 233, 1982.
rat LD50 intraperitoneal 318mg/kg (318mg/kg)   Drugs in Japan Vol. 6, Pg. 233, 1982.
rat LD50 oral 1500mg/kg (1500mg/kg)   "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 35, 1969.
rat LD50 subcutaneous 1630mg/kg (1630mg/kg)   Drugs in Japan Vol. 6, Pg. 233, 1982.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point < 25 deg C   EXP
log P (octanol-water) 2.730 (none)   EST
Atmospheric OH Rate Constant 3.92E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.