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Substance Name: Metyrosine [USAN:USP]
RN: 672-87-7
UNII: DOQ0J0TPF7
InChIKey: NHTGHBARYWONDQ-JTQLQIEISA-N

Note

  • An inhibitor of the enzyme TYROSINE 3-MONOOXYGENASE, and consequently of the synthesis of catecholamines. It is used to control the symptoms of excessive sympathetic stimulation in patients with PHEOCHROMOCYTOMA. (Martindale, The Extra Pharmacopoeia, 30th ed)

Molecular Formula

  • C10-H13-N-O3

Molecular Weight

  • 195.2167
 

Classification Codes

  • Antihypertensive
  • Enzyme Inhibitors
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Names and Synonyms

Name of Substance

  • Metirosine [INN]
  • Metyrosine [USAN:USP]

MeSH Heading

  • alpha-Methyltyrosine

Synonyms

  • (-)-(S)-2-Amino-3-(4-hydroxyphenyl)-2-methylpropionsaeure
  • (-)-alpha-Methyl-L-tyrosine
  • (S)-alpha-Methyltyrosine
  • alpha-Methyl-paratyrosine
  • Demser
  • EINECS 211-599-5
  • L 588357-0
  • L-588357-0
  • L-alpha-Methyltyrosine
  • Metirosina
  • Metirosina [INN-Spanish]
  • Metirosine
  • Metirosinum
  • Metirosinum [INN-Latin]
  • Metyrosine
  • MK 781
  • MK-781
  • UNII-DOQ0J0TPF7

Systematic Names

  • L-Tyrosine, alpha-methyl-, (-)-
  • Metirosine

Registry Numbers

CAS Registry Number

  • 672-87-7

FDA UNII

  • DOQ0J0TPF7

Other Registry Numbers

  • 23239-48-7
  • 5380-13-2

System Generated Number

  • 0000672877

Structure Descriptors

InChI

InChI=1S/C10H13NO3/c1-10(11,9(13)14)6-7-2-4-8(12)5-3-7/h2-5,12H,6,11H2,1H3,(H,13,14)/t10-/m0/s1

InChIKey

NHTGHBARYWONDQ-JTQLQIEISA-N

Smiles

C[C@](N)(Cc1ccc(O)cc1)C(=O)O

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 312.5 deg C   EXP
log P (octanol-water) -1.310 (none)   EST
Atmospheric OH Rate Constant 6.36E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.