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Substance Name: Nylidrin hydrochloride [USP]
RN: 849-55-8
UNII: EC69E3PW7E
InChIKey: CLJHABUMMDMAFA-UHFFFAOYSA-N

Note

  • A beta-adrenergic agonist. Nylidrin causes peripheral vasodilation, a positive inotropic effect, and increased gastric volume of gastric juice. It is used in the treatment of peripheral vascular disorders and premature labor.

Molecular Formula

  • C19-H25-N-O2.Cl-H

Molecular Weight

  • 335.872
 

Classification Code

  • Drug / Therapeutic Agent
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Names and Synonyms

Name of Substance

  • Nylidrin hydrochloride
  • Nylidrin hydrochloride [USP]

Synonyms

  • 1-p-Hydroxyphenyl-2-(1'-methyl-3'-phenylpropylamino)-1-propanol hydrochloride
  • Arlibide
  • Arlidin
  • Benzenemethanol, 4-hydroxy-alpha-(1-((1-methyl-3-phenylpropyl)amino)ethyl)-, hydrochloride
  • Bufedon
  • Buphedrin
  • Buphenin hydrochloride
  • Buphenine hydrochloride
  • Dilatol
  • Dilydrin
  • EINECS 212-701-0
  • NSC 142004
  • Nylidrin HCl
  • Nylidrin hydrochloride
  • p-Hydroxy-alpha-(1-((1-methyl-3-phenylpropyl)amino)ethyl)benzyl alcohol hydrochloride
  • Penitardon
  • Rolidrin
  • Rudilin
  • Suprifen psb hydrochloride
  • Tocodilydrin
  • Tocodrin
  • UNII-EC69E3PW7E
  • Vasiten
  • Verina

Systematic Names

  • Benzenemethanol, 4-hydroxy-alpha-(1-((1-methyl-3-phenylpropyl)amino)ethyl)-, hydrochloride
  • Benzyl alcohol, p-hydroxy-alpha-(1-((1-methyl-3-phenylpropyl)amino)ethyl)-, hydrochloride
  • Buphenine hydrochloride

Registry Numbers

CAS Registry Number

  • 849-55-8

FDA UNII

  • EC69E3PW7E

Other Registry Numbers

  • 3595-06-0
  • 900-01-6
  • 91408-84-3

Related Registry Number

  • 447-41-6 (Parent)

System Generated Number

  • 0000849558

Molecular Formulas

Molecular Formula

  • C19-H25-N-O2.Cl-H

Molecular Formula Fragments

  • C19-H25-N-O2
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

InChI=1S/C19H25NO2.ClH/c1-14(8-9-16-6-4-3-5-7-16)20-15(2)19(22)17-10-12-18(21)13-11-17;/h3-7,10-15,19-22H,8-9H2,1-2H3;1H

InChIKey

CLJHABUMMDMAFA-UHFFFAOYSA-N

Smiles

[Cl-].CC(CCc1ccccc1)[NH2+]C(C)C(O)c2ccc(O)cc2

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 136mg/kg (136mg/kg)   Yakkyoku. Pharmacy. Vol. 24, Pg. 431, 1973.
mouse LD50 intravenous 40mg/kg (40mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 351, 1972.
mouse LD50 oral 250mg/kg (250mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 351, 1972.
rat LD50 intraperitoneal 380mg/kg (380mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 351, 1972.
rat LD50 intravenous 37400ug/kg (37.4mg/kg)   United States Patent Document. Vol. #3542870,
rat LD50 oral > 4800mg/kg (4800mg/kg)   Drugs in Japan Vol. 6, Pg. 538, 1982.