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Substance Name: Lumacaftor [USAN:INN]
RN: 936727-05-8
UNII: EGP8L81APK
InChIKey: UFSKUSARDNFIRC-UHFFFAOYSA-N

Note

  • A corrector of CF transmembrane conductance regulator (CTFR).

Classification Code

  • Treatment of Cystic Fibrosis

Molecular Formula

  • C24-H18-F2-N2-O5

Molecular Weight

  • 452.4112
 
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Names and Synonyms

Name of Substance

  • Lumacaftor [USAN:INN]

Synonyms

  • 3-(6-(1-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropane-1-carboxamido)-3-methylpyridin-2-yl)benzoic acid
  • Benzoic acid, 3-(6-(((1-(2,2-difluoro-1,3-benzodioxol-5-yl)cyclopropyl)carbonyl)amino)-3-methyl-2-pyridinyl)-
  • Lumacaftor
  • UNII-EGP8L81APK
  • VRT 826809
  • VRT-826809
  • VX 809
  • VX-809

Registry Numbers

CAS Registry Number

  • 936727-05-8

FDA UNII

  • EGP8L81APK

System Generated Number

  • 0936727058

Structure Descriptors

InChI

1S/C24H18F2N2O5/c1-13-5-8-19(27-20(13)14-3-2-4-15(11-14)21(29)30)28-22(31)23(9-10-23)16-6-7-17-18(12-16)33-24(25,26)32-17/h2-8,11-12H,9-10H2,1H3,(H,29,30)(H,27,28,31)

InChIKey

UFSKUSARDNFIRC-UHFFFAOYSA-N

Smiles

Cc1ccc(nc1c2cccc(c2)C(=O)O)NC(=O)C3(CC3)c4ccc5c(c4)OC(O5)(F)F