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Substance Name: Vidarabine [USAN:USP:INN:BAN:JAN]
RN: 24356-66-9
UNII: FA2DM6879K
InChIKey: ZTHWFVSEMLMLKT-CAMOTBBTSA-N

Note

  • A nucleoside antibiotic isolated from Streptomyces antibioticus. It has some antineoplastic properties and has broad spectrum activity against DNA viruses in cell cultures and significant antiviral activity against infections caused by a variety of viruses such as the herpes viruses, the VACCINIA VIRUS and varicella zoster virus.

Molecular Formula

  • C10-H13-N5-O4.H2-O

Molecular Weight

  • 285.2585
 

Classification Codes

  • Anti-Infective Agents
  • Antimetabolites
  • Antiviral
  • Antiviral Agents
  • Drug / Therapeutic Agent
  • Noxae
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Names and Synonyms

Name of Substance

  • Vidarabine [USAN:USP:INN:BAN:JAN]

MeSH Heading

  • Vidarabine

Synonyms

  • 9-beta-D-Arabinofuranosyl-9H-purine-6-amine monohydrate
  • 9-beta-D-Arabinofuranosyladenine monohydrate
  • 9H-Purin-6-amine, 9-beta-D-arabinofuranosyl-, monohydrate
  • Adenine arabinofuranoside hydrate
  • Adenine, 9-beta-D-arabinofuranosyl-, monohydrate
  • Ara-A
  • CI 673
  • DRG-0058
  • NSC 757383
  • Spongoadenosine
  • UNII-FA2DM6879K
  • Vidarabine
  • Vira-A

Systematic Names

  • 9H-Purin-6-amine, 9-beta-D-arabinofuranosyl-, monohydrate
  • Adenine, 9-beta-D-arabinofuranosyl-, monohydrate

Registry Numbers

CAS Registry Number

  • 24356-66-9

FDA UNII

  • FA2DM6879K

System Generated Number

  • 0024356669

Molecular Formulas

Molecular Formula

  • C10-H13-N5-O4.H2-O

Molecular Formula Fragments

  • C10-H13-N5-O4
  • COMPONENT
  • H2-O

Structure Descriptors

InChI

InChI=1S/C10H13N5O4.H2O/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10;/h2-4,6-7,10,16-18H,1H2,(H2,11,12,13);1H2/t4-,6-,7+,10-;/m1./s1

InChIKey

ZTHWFVSEMLMLKT-CAMOTBBTSA-N

Smiles

O.Nc1ncnc2c1ncn2[C@@H]3O[C@H](CO)[C@@H](O)[C@@H]3O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 4677mg/kg (4677mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

GASTROINTESTINAL: PERITONITIS
Antimicrobial Agents and Chemotherapy Vol. -, Pg. 180, 1968.
mouse LD50 oral > 7950mg/kg (7950mg/kg)   Antimicrobial Agents and Chemotherapy Vol. -, Pg. 180, 1968.