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Substance Name: Diethyltoluamide [USP:INN:BAN]
RN: 134-62-3
UNII: FB0C1XZV4Y
InChIKey: MMOXZBCLCQITDF-UHFFFAOYSA-N

Note

  • A compound used as a topical insect repellent that may cause irritation to eyes and mucous membranes, but not to the skin.

Molecular Formula

  • C12-H17-N-O

Molecular Weight

  • 191.2723
 

Classification Codes

  • Agricultural Chemical
  • Human Data
  • Insect Attractant, Repellent and Chemosterilant
  • Insect Repellents
  • Mutation Data
  • Pesticides
  • Protective Agents
  • Repellant, Arthropod
  • Reproductive Effect
  • Skin / Eye Irritant

Names and Synonyms

Name of Substance

  • Benzamide, N,N-diethyl-3-methyl-
  • DEET
  • Diethyl toluamide
  • Diethyltoluamide [USP:INN:BAN]
  • m-Delphene
  • N,N-Diethyl-3-methylbenzamide
  • N,N-Diethyl-m-toluamide

MeSH Heading

  • DEET

Synonyms

  • 3-Methyl-N,N-diethylbenzamide
  • 4-09-00-01716 (Beilstein Handbook Reference)
  • AI 3-22542
  • Amincene C 140
  • Amincene C-EM
  • Autan
  • Benzamide, N,N-diethyl-3-methyl-
  • Bepper DET
  • BRN 2046711
  • Caswell No. 346
  • CCRIS 6018
  • DEET
  • Delphene
  • DET (insect repellant)
  • DETA
  • DETA-20
  • Detamide
  • Dieltamid
  • Diethyl-m-toluamide
  • Diethyltoluamide
  • Diethyltoluamidum
  • Diethyltoluamidum [INN-Latin]
  • Dietiltoluamida
  • Dietiltoluamida [INN-Spanish]
  • EINECS 205-149-7
  • ENT 20,218
  • ENT 22542
  • EPA Pesticide Chemical Code 080301
  • Flypel
  • HSDB 1582
  • m-Delphene
  • M-Det
  • m-DETA
  • m-Toluamide, N,N-diethyl-
  • m-Toluic acid diethylamide
  • Metadelphene
  • MGK
  • MGK diethyltoluamide
  • Muscol
  • N,N-Diethyl-3-methylbenzamide
  • N,N-Diethyl-m-toluamide
  • N,N-Diethyl-meta-toluamide
  • Naugatuck DET
  • NSC 33840
  • Off
  • Repel
  • Repper DET
  • Repper-DET
  • Repudin-Special
  • UNII-FB0C1XZV4Y

Systematic Names

  • Benzamide, N,N-diethyl-3-methyl-
  • m-Toluamide, N,N-diethyl-
  • N,N-Diethyl-m-toluamide

Superlist Names

  • m-Toluamide, N,N-diethyl-
  • N,N-Diethyl-meta-toluamide and other isomers

Registry Numbers

CAS Registry Number

  • 134-62-3

FDA UNII

  • FB0C1XZV4Y

Other Registry Number

  • 94271-03-1

System Generated Number

  • 0000134623

Structure Descriptors

InChI

InChI=1S/C12H17NO/c1-4-13(5-2)12(14)11-8-6-7-10(3)9-11/h6-9H,4-5H2,1-3H3

InChIKey

MMOXZBCLCQITDF-UHFFFAOYSA-N

Smiles

CCN(CC)C(=O)c1cccc(C)c1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child TDLo oral 4750mg/kg (4750mg/kg) BEHAVIORAL: COMA

BEHAVIORAL: STIFFNESS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 JAMA, Journal of the American Medical Association. Vol. 258, Pg. 1509, 1987.
human TDLo skin 35mg/kg/5D (35mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" Toxicology and Applied Pharmacology. Vol. 1, Pg. 97, 1959.
mammal (species unspecified) LD50 oral 1800mg/kg (1800mg/kg)   United States Patent Document. Vol. #3594481,
man LDLo oral 679mg/kg (679mg/kg)   JAMA, Journal of the American Medical Association. Vol. 258, Pg. 1509, 1987.
mouse LD50 oral 1170mg/kg (1170mg/kg)   Yakkyoku. Pharmacy. Vol. 36, Pg. 1671, 1985.
mouse LD50 skin 3170uL/kg (3.17mL/kg)   Yakkyoku. Pharmacy. Vol. 31, Pg. 309, 1980.
rabbit LD50 oral 1584mg/kg (1584mg/kg)   National Technical Information Service. Vol. AD-A082-131,
rabbit LD50 oral 1584mg/kg (1584mg/kg)   National Technical Information Service. Vol. AD-A082-131,
rabbit LD50 skin 3180uL/kg (3.18mL/kg)   Toxicology and Applied Pharmacology. Vol. 28, Pg. 313, 1974.
rabbit LDLo intravenous 75mg/kg (75mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: TREMOR

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)		 Toxicology and Applied Pharmacology. Vol. 1, Pg. 97, 1959.
rat LC50 inhalation 5950mg/m3 (5950mg/m3)   National Technical Information Service. Vol. AD-079-960,
rat LD50 oral 1950mg/kg (1950mg/kg)   Special Publication of the Entomological Society of America. Vol. 78-1, Pg. 53, 1978.
rat LD50 skin 5gm/kg (5000mg/kg)   Meditsinskaya Parazitologiya i Parazitarnye Bolezni. Medical Parasitology and Parasitic Diseases. Vol. 45, Pg. 65, 1976.
women LDLo oral 950mg/kg (950mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

BEHAVIORAL: COMA

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES		 JAMA, Journal of the American Medical Association. Vol. 258, Pg. 1509, 1987.
women TDLo oral 300ug/kg (0.3mg/kg) VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION

CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE

CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP		 Journal of Analytical Toxicology. Vol. 19, Pg. 197, 1995.
women TDLo oral 950mg/kg (950mg/kg) BEHAVIORAL: COMA

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES		 JAMA, Journal of the American Medical Association. Vol. 258, Pg. 1509, 1987.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point -4.50E+01 deg C   EXP
Boiling Point 290 deg C   EXP
log P (octanol-water) 2.18 (none)   EXP
Water Solubility 912 mg/L 25 EST
Vapor Pressure 0.002 mm Hg 25 EXP
Henry's Law Constant 2.08E-08 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 2.53E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.