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Substance Name: Valganciclovir [INN:BAN]
RN: 175865-60-8
UNII: GCU97FKN3R
InChIKey: WPVFJKSGQUFQAP-GKAPJAKFSA-N

Notes

  • A ganciclovir prodrug and antiviral agent that is used to treat CYTOMEGALOVIRUS RETINITIS in patients with AIDS, and for the prevention of CYTOMEGALOVIRUS INFECTIONS in organ transplant recipients who have received an organ from a CMV-positive donor.
  • NCI: A synthetic prodrug of ganciclovir, a nucleoside analogue of 2'-deoxyguanosine, with antiviral activity. After phosphorylation, valganciclovir is incorporated into DNA, resulting in inhibition of viral DNA polymerase, viral DNA synthesis, and viral replication. (NCI Thesaurus)

Molecular Formula

  • C14-H22-N6-O5

Molecular Weight

  • 354.365
 

Classification Codes

  • Anti-Infective Agents
  • Antiviral Agents

Names and Synonyms

Name of Substance

  • Valganciclovir
  • Valganciclovir [INN:BAN]

MeSH Heading

  • Valganciclovir

Synonyms

  • HSDB 8085
  • UNII-GCU97FKN3R
  • Valganciclovir

Systematic Name

  • L-Valine, 2-((2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy)-3-hydroxypropyl ester

Registry Numbers

CAS Registry Number

  • 175865-60-8

FDA UNII

  • GCU97FKN3R

System Generated Number

  • 0175865608

Structure Descriptors

InChI

InChI=1S/C14H22N6O5/c1-7(2)9(15)13(23)24-4-8(3-21)25-6-20-5-17-10-11(20)18-14(16)19-12(10)22/h5,7-9,21H,3-4,6,15H2,1-2H3,(H3,16,18,19,22)/t8?,9-/m0/s1

InChIKey

WPVFJKSGQUFQAP-GKAPJAKFSA-N

Smiles

CC(C)[C@H](N)C(=O)OCC(CO)OCn1cnc2C(=O)N=C(N)Nc12