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Substance Name: Zaltoprofen [INN]
RN: 74711-43-6
UNII: H8635NG3PY
InChIKey: MUXFZBHBYYYLTH-UHFFFAOYSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formula

  • C17-H14-O3-S

Molecular Weight

  • 298.3606
 
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Names and Synonyms

Results Name

  • Zaltoprofen [INN]

Name of Substance

  • CN 100
  • Zaltoprofen (+-)-
  • Zaltoprofen (unspecified)
  • Zaltoprofen sodium salt
  • Zaltoprofen [INN:JAN]
  • Zaltoprofen [INN]

Synonyms

  • (+-)-10,11-Dihydro-alpha-methyl-10-oxodibenzo(b,f)thiepin-2-acetic acid
  • (+-)-2-(10,11-Dihydro-10-oxodibenzo(b,f)thiepin-2-yl)propionic acid
  • 10,11-Dihydro-alpha-methyl-10-oxodibenzo(b,f)thiepin-2-acetic acid
  • CN-100
  • EINECS 277-973-5
  • Soleton
  • UNII-H8635NG3PY
  • Zaltoprofen
  • Zaltoprofene
  • Zaltoprofene [INN-French]
  • Zaltoprofeno
  • Zaltoprofeno [INN-Spanish]
  • Zaltoprofenum
  • Zaltoprofenum [INN-Latin]

Systematic Names

  • (+-)-10,11-Dihydro-alpha-methyl-10-oxodibenzo(b,f)thiepin-2-acetic acid
  • 10,11-Dihydro-alpha-methyl-10-oxodibenzo(b,f)thiepin-2-acetic acid
  • Dibenzo(b,f)thiepin-2-acetic acid, 10,11-dihydro-alpha-methyl-10-oxo-

Registry Numbers

CAS Registry Number

  • 74711-43-6

FDA UNII

  • H8635NG3PY

Other Registry Number

  • 89482-00-8

System Generated Number

  • 0074711436

Structure Descriptors

InChI

InChI=1S/C17H14O3S/c1-10(17(19)20)11-6-7-15-12(8-11)9-14(18)13-4-2-3-5-16(13)21-15/h2-8,10H,9H2,1H3,(H,19,20)

InChIKey

MUXFZBHBYYYLTH-UHFFFAOYSA-N

Smiles

CC(C(=O)O)c1ccc2Sc3ccccc3C(=O)Cc2c1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo oral > 1gm/kg (1000mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

GASTROINTESTINAL: NAUSEA OR VOMITING
Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 6026, 1990.
mouse LD50 intraperitoneal 214mg/kg (214mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

BLOOD: CHANGES IN SPLEEN

GASTROINTESTINAL: ULCERATION OR BLEEDING FROM LARGE INTESTINE
Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 5979, 1990.
mouse LD50 oral 410mg/kg (410mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

BLOOD: CHANGES IN SPLEEN

LUNGS, THORAX, OR RESPIRATION: CYANOSIS
Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 5979, 1990.
mouse LD50 subcutaneous 781mg/kg (781mg/kg) GASTROINTESTINAL: NECROTIC GHANGES

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BLOOD: CHANGES IN SPLEEN
Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 5979, 1990.
rat LD50 intraperitoneal 217mg/kg (217mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: ATAXIA

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 5979, 1990.
rat LD50 oral 425mg/kg (425mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE

BLOOD: CHANGES IN SPLEEN
Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 5979, 1990.
rat LD50 subcutaneous 427mg/kg (427mg/kg) BLOOD: CHANGES IN SPLEEN

SKIN AND APPENDAGES (SKIN): HAIR: OTHER

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 5979, 1990.