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Substance Name: Nelfinavir [INN:BAN]
RN: 159989-64-7
UNII: HO3OGH5D7I
InChIKey: QAGYKUNXZHXKMR-HKWSIXNMSA-N
Note
- A potent HIV protease inhibitor. It is used in combination with other antiviral drugs in the treatment of HIV in both adults and children.
Molecular Formula
- C32-H45-N3-O4-S
Molecular Weight
- 567.7905
Classification Codes
- Anti-HIV Agents
- Anti-Infective Agents
- Anti-Retroviral Agents
- Antiviral (COVID-19)
- Antiviral Agents
- Enzyme Inhibitors
- HIV Protease Inhibitors
- Protease Inhibitors
- Viral Protease Inhibitors
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Names and Synonyms
Name of Substance
- Nelfinavir
- Nelfinavir [INN:BAN]
MeSH Heading
- Nelfinavir
Synonyms
- (3S-(2(2S*,3S*),3alpha,4abeta,8abeta))-N-(1,1-Dimethylethyl)decahydro-2-(2-hydroxy-3-((3-hydroxy-2-methylbenzoyl)amino)-4-(phenylthio)butyl)-3-isoquinolinecarboxamide
- AG 1343
- AG-1343
- N-(1,1-Dimethylethyl)decahydro-2-(2-hydroxy-3-((3-hydroxy-2-methylbenzoyl)amino)-4-(phenylthio)butyl)-3-isoquinolinecarboxamide (3S-(2(2S*,3S*),3alpha,4abeta,8abeta))-
- Nelfinavir
- NSC 747167
- UNII-HO3OGH5D7I
- Viracept
Systematic Names
- 3-Isoquinolinecarboxamide, N-(1,1-dimethylethyl)decahydro-2-((2R,3R)-2-hydroxy-3-((3-hydroxy-2-methylbenzoyl)amino)-4-(phenylthio)butyl)-, (3S,4aS,8aS)-
- 3-Isoquinolinecarboxamide, N-(1,1-dimethylethyl)decahydro-2-(2-hydroxy-3-((3-hydroxy-2-methylbenzoyl)amino)-4-(phenylthio)butyl)-, (3S-(2-(2S*,3S*),3-alpha,4a-beta,8a-beta))-
Registry Numbers
CAS Registry Number
- 159989-64-7
FDA UNII
- HO3OGH5D7I
Related Registry Number
- 159989-65-8 (monomethane sulfonate (salt))
System Generated Number
- 0159989647
Structure Descriptors
InChI
InChI=1S/C32H45N3O4S/c1-21-25(15-10-16-28(21)36)30(38)33-26(20-40-24-13-6-5-7-14-24)29(37)19-35-18-23-12-9-8-11-22(23)17-27(35)31(39)34-32(2,3)4/h5-7,10,13-16,22-23,26-27,29,36-37H,8-9,11-12,17-20H2,1-4H3,(H,33,38)(H,34,39)/t22-,23+,26-,27-,29+/m0/s1InChIKey
QAGYKUNXZHXKMR-HKWSIXNMSA-NSmiles
Cc1c(O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
rat | LD | oral | > 5gm/kg (5000mg/kg) | Toxicologist. Vol. 42, Pg. 55, 1998. |