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Substance Name: Flurbiprofen axetil
RN: 91503-79-6
UNII: I0OU31PUI5
InChIKey: ALIVXCSEERJYHU-UHFFFAOYSA-N

Note

  • An analgesic.

Molecular Formula

  • C19-H19-F-O4

Molecular Weight

  • 330.353
 

Classification Codes

  • Analgesics
  • Analgesics, Non-Narcotic
  • Anti-Inflammatory Agents
  • Anti-Inflammatory Agents, Non-Steroidal
  • Antirheumatic Agents
  • Drug / Therapeutic Agent
  • Peripheral Nervous System Agents
  • Reproductive Effect
  • Sensory System Agents
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Names and Synonyms

Results Name

  • Flurbiprofen axetil

Name of Substance

  • FP 83

Synonyms

  • 1-Acetoxyethyl 2-(2-fluoro-4-biphenylyl)propionate
  • 1-acetoxyethyl-2-(2-fluoro-4-biphenyl)propionate
  • 1-Acetoxyethyl-2-(2-fluoro-4-biphenylyl)propionate
  • 2-Fluoro-alpha-methyl-(1,1'-biphenyl)-4-acetic acid 1-(acetyloxy)ethyl ester
  • 4-Biphenylacetic acid, 2-fluoro-alpha-methyl-, 1-acetoxyethyl ester
  • Flurbiprofen axetil
  • FP-83
  • FP83
  • LFP 83
  • LFP83
  • Lipfen
  • Lipo-flurbiprofen axetil
  • Liposomal flurbiprofen axetil
  • Ropion
  • UNII-I0OU31PUI5

Systematic Name

  • (1,1'-Biphenyl)-4-acetic acid, 2-fluoro-alpha-methyl-, 1-(acetyloxy)ethyl ester

Registry Numbers

CAS Registry Number

  • 91503-79-6

FDA UNII

  • I0OU31PUI5

System Generated Number

  • 0091503796

Structure Descriptors

InChI

InChI=1S/C19H19FO4/c1-12(19(22)24-14(3)23-13(2)21)16-9-10-17(18(20)11-16)15-7-5-4-6-8-15/h4-12,14H,1-3H3

InChIKey

ALIVXCSEERJYHU-UHFFFAOYSA-N

Smiles

CC(OC(=O)C)OC(=O)C(C)c1ccc(c(F)c1)c2ccccc2

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
monkey LD50 intravenous 188mg/kg (188mg/kg) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. Vol. 14, Pg. 81, 1988.
mouse LD50 intravenous 194mg/kg (194mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Kiso to Rinsho. Clinical Report. Vol. 22, Pg. 3949, 1988.
mouse LD50 oral 69mg/kg (69mg/kg) BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Kiso to Rinsho. Clinical Report. Vol. 22, Pg. 3949, 1988.
mouse LD50 subcutaneous 183mg/kg (183mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Kiso to Rinsho. Clinical Report. Vol. 22, Pg. 3949, 1988.
rat LD50 intravenous 88mg/kg (88mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Kiso to Rinsho. Clinical Report. Vol. 22, Pg. 3949, 1988.
rat LD50 oral 66mg/kg (66mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Kiso to Rinsho. Clinical Report. Vol. 22, Pg. 3949, 1988.
rat LD50 subcutaneous 66mg/kg (66mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Kiso to Rinsho. Clinical Report. Vol. 22, Pg. 3949, 1988.