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Substance Name: Irbesartan [USAN:USP:INN:BAN]
RN: 138402-11-6
UNII: J0E2756Z7N
InChIKey: YOSHYTLCDANDAN-UHFFFAOYSA-N

Note

  • A spiro compound, biphenyl and tetrazole derivative that acts as an angiotensin II type 1 receptor antagonist. It is used in the management of HYPERTENSION, and in the treatment of kidney disease.

Molecular Formula

  • C25-H28-N6-O

Molecular Weight

  • 428.5372
 

Classification Codes

  • Angiotensin II Type 1 Receptor Blockers
  • Angiotensin Receptor Antagonists
  • Antihypertensive (Angiotensin II Receptor Antagonist)
  • Antihypertensive Agents
  • Antiviral (COVID-19)
  • Cardiovascular Agents

Names and Synonyms

Name of Substance

  • Irbesartan
  • Irbesartan [USAN:USP:INN:BAN]

MeSH Heading

  • Irbesartan

Synonyms

  • 1,3-Diazaspiro(4.4)non-1-en-4-one, 2-butyl-3-((2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-
  • 2-Butyl-3-(p-(o-1H-tetrazol-5-ylphenyl)benzyl)-1,3-diazaspiro(4.4)non-1-en-4-one
  • Aprovel
  • Avapro
  • BMS 186295
  • BMS-186295
  • HSDB 8215
  • Irbesartan
  • Irbesartan BMS
  • Irbesartan Krka
  • Irbesartan Winthrop
  • Karvea
  • NSC 758696
  • SR 47436
  • SR-47436
  • UNII-J0E2756Z7N

Systematic Names

  • 1,3-Diazaspiro(4.4)non-1-en-4-one, 2-butyl-3-((2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-
  • 2-Butyl-3-(p-(o-1H-tetrazol-5-ylphenyl)benzyl)-1,3-diazaspiro(4.4)non-1-en-4-one

Registry Numbers

CAS Registry Number

  • 138402-11-6

FDA UNII

  • J0E2756Z7N

System Generated Number

  • 0138402116

Structure Descriptors

InChI

InChI=1S/C25H28N6O/c1-2-3-10-22-26-25(15-6-7-16-25)24(32)31(22)17-18-11-13-19(14-12-18)20-8-4-5-9-21(20)23-27-29-30-28-23/h4-5,8-9,11-14H,2-3,6-7,10,15-17H2,1H3,(H,27,28,29,30)

InChIKey

YOSHYTLCDANDAN-UHFFFAOYSA-N

Smiles

CCCCC1=NC2(CCCC2)C(=O)N1Cc3ccc(cc3)c4ccccc4c5nnn[nH]5