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Substance Name: Desonide [USAN:INN:BAN]
RN: 638-94-8
UNII: J280872D1O
InChIKey: WBGKWQHBNHJJPZ-LECWWXJVSA-N

Note

  • A nonfluorinated corticosteroid anti-inflammatory agent used topically for DERMATOSES.

Molecular Formula

  • C24-H32-O6

Molecular Weight

  • 416.5108
 

Classification Codes

  • Anti-Inflammatory
  • Anti-Inflammatory Agents
  • Drug / Therapeutic Agent

Names and Synonyms

Name of Substance

  • Desonide
  • Desonide [USAN:INN:BAN]

MeSH Heading

  • Desonide

Synonyms

  • 11beta,16alpha,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with acetone
  • 16-alpha-Hydroxyprednisole-16,17-acetonide
  • Apolar
  • D 2083
  • D-2083
  • D2083
  • Desilux
  • Desonate
  • Desonida
  • Desonida [INN-Spanish]
  • Desonide
  • Desonidum
  • Desonidum [INN-Latin]
  • DesOwen
  • EINECS 211-351-6
  • Flusemidon
  • Hamiltoderm
  • Locapred
  • Prednacinolone
  • Prenacid
  • Reticus
  • Sterax
  • Steroderm
  • Topifug
  • Tridesilon
  • Tridesonit
  • UNII-J280872D1O
  • Verdeso
  • Zotinar

Systematic Names

  • Desonide
  • Prednisolone-16,17-acetonide, 16-alpha-hydroxy-
  • Pregna-1,4-diene-3,20-dione, 11,21-dihydroxy-16,17-((1-methylethylidene)bis(oxy))-, (11beta,16alpha)-

Mixture Name

  • Otic Tridesilon

Registry Numbers

CAS Registry Number

  • 638-94-8

FDA UNII

  • J280872D1O

System Generated Number

  • 0000638948

Structure Descriptors

InChI

InChI=1S/C24H32O6/c1-21(2)29-19-10-16-15-6-5-13-9-14(26)7-8-22(13,3)20(15)17(27)11-23(16,4)24(19,30-21)18(28)12-25/h7-9,15-17,19-20,25,27H,5-6,10-12H2,1-4H3/t15-,16-,17-,19+,20+,22-,23-,24+/m0/s1

InChIKey

WBGKWQHBNHJJPZ-LECWWXJVSA-N

Smiles

CC1(C)O[C@@H]2C[C@H]3[C@@H]4CCC5=CC(=O)C=C[C@]5(C)[C@H]4[C@@H](O)C[C@]3(C)[C@@]2(O1)C(=O)CO

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 oral 3710mg/kg (3710mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 111, 1970.
rat LD50 subcutaneous 93mg/kg (93mg/kg)   Toxicology and Applied Pharmacology. Vol. 20, Pg. 522, 1971.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 274 deg C   EXP
log P (octanol-water) 2.790 (none)   EST
Atmospheric OH Rate Constant 9.36E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.