|
|
Substance Name: Morphine hydrochloride [USP:JAN]
RN: 52-26-6
UNII: J28GE0ROVX
InChIKey: XCKKIKBIPZJUET-VYKNHSEDSA-N
Note
- The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle.
Molecular Formula
- C17-H19-N-O3.Cl-H
Molecular Weight
- 321.802
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Formulas
- Structure Descriptors
- Toxicity
Classification Codes
- Drug / Therapeutic Agent
- Human Data
- Mutation Data
- Reproductive Effect
* denotes mobile formatted website
Links to Resources
NLM Resources (File Locators)
Regulatory Agencies (Superlist Locators)
Other Resources (Internet Locators)
Search for this InChIKey on the Web
Names and Synonyms
Name of Substance
- Morphine hydrochloride [USP:JAN]
Synonyms
- Ampek
- EINECS 200-136-2
- Morphinan-3,6-alpha-diol, 7,8-didehydro-4,5-alpha-epoxy-17-methyl-, hydrochloride
- Morphine chlorhydrate
- Morphine chloride
- Morphine HCl
- Morphine hydrochloride
- Theba-Intran
- Thebametten
- UNII-J28GE0ROVX
Systematic Names
- Morphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-17-methyl-, hydrochloride, (5-alpha,6-alpha)-
- Morphine hydrochloride
Registry Numbers
CAS Registry Number
- 52-26-6
FDA UNII
- J28GE0ROVX
System Generated Number
- 0000052266
Molecular Formulas
Molecular Formula
- C17-H19-N-O3.Cl-H
Molecular Formula Fragments
- C17-H19-N-O3
- Cl-H
- COMPONENT
Structure Descriptors
InChI
InChI=1S/C17H19NO3.ClH/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18;/h2-5,10-11,13,16,19-20H,6-8H2,1H3;1H/t10-,11+,13-,16-,17-;/m0./s1InChIKey
XCKKIKBIPZJUET-VYKNHSEDSA-NSmiles
Cl.CN1CC[C@]23[C@H]4Oc5c(O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
dog | LD50 | intravenous | 175mg/kg (175mg/kg) | Chemical and Pharmaceutical Bulletin. Vol. 7, Pg. 372, 1959. | |
guinea pig | LD50 | subcutaneous | 340mg/kg (340mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 137, Pg. 375, 1962. | |
guinea pig | LDLo | intraarterial | 60mg/kg (60mg/kg) | Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 131, Pg. 171, 1928. | |
guinea pig | LDLo | intravenous | 60mg/kg (60mg/kg) | Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 131, Pg. 171, 1928. | |
mouse | LD50 | intracrebral | 3500ug/kg (3.5mg/kg) | Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 63(3), Pg. 93S, 1967. | |
mouse | LD50 | intraperitoneal | 148mg/kg (148mg/kg) | British Journal of Pharmacology. Vol. 73, Pg. 887, 1981. | |
mouse | LD50 | intravenous | 180mg/kg (180mg/kg) | Archives of Toxicology, Supplement. Vol. 7, Pg. 90, 1984. | |
mouse | LD50 | oral | 745mg/kg (745mg/kg) | Japanese Journal of Pharmacology. Vol. 18, Pg. 406, 1968. | |
mouse | LD50 | parenteral | 440mg/kg (440mg/kg) | Wakayama Medical Report. Vol. 26(4), Pg. 65, 1983. | |
mouse | LD50 | subcutaneous | 354mg/kg (354mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 5, Pg. 1787, 1971. | |
rabbit | LD50 | intraperitoneal | 500mg/kg (500mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Journal of Pharmacology and Experimental Therapeutics. Vol. 60, Pg. 14, 1937. |
rabbit | LD50 | intravenous | 135mg/kg (135mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 85, Pg. 387, 1951. |
rabbit | LD50 | subcutaneous | 398mg/kg (398mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Journal of Pharmacology and Experimental Therapeutics. Vol. 66, Pg. 182, 1939. |
rabbit | LDLo | oral | 700mg/kg (700mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: FOOD INTAKE (ANIMAL) BEHAVIORAL: MUSCLE WEAKNESS | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 14, Pg. 289, 1905. |
rat | LD50 | intravenous | 265mg/kg (265mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 115, Pg. 213, 1958. | |
rat | LD50 | oral | 335mg/kg (335mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 221, Pg. 105, 1976. | |
rat | LD50 | subcutaneous | 480mg/kg (480mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 115, Pg. 213, 1958. | |
rat | LD50 | unreported | 310mg/kg (310mg/kg) | BEHAVIORAL: ANALGESIA | Pharmacological Research Communications. Vol. 5, Pg. 175, 1973. |
rat | LDLo | intraspinal | 2mg/kg (2mg/kg) | BEHAVIORAL: ANALGESIA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: IRRITABILITY | Acta Pharmacologica et Toxicologica. Vol. 56, Pg. 50, 1985. |
women | TDLo | intraspinal | 40ug/kg (0.04mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE | Israel Journal of Medical Sciences. Vol. 21, Pg. 855, 1985. |
women | TDLo | parenteral | 720ug/kg/3D-I (0.72mg/kg) | SKIN AND APPENDAGES (SKIN): HAIR: OTHER | Anesthesia and Analgesia Vol. 63, Pg. 1142, 1984. |