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Substance Name: Succinylcholine
RN: 306-40-1
UNII: J2R869A8YF
InChIKey: AXOIZCJOOAYSMI-UHFFFAOYSA-N

Note

  • A quaternary skeletal muscle relaxant usually used in the form of its bromide, chloride, or iodide. It is a depolarizing relaxant, acting in about 30 seconds and with a duration of effect averaging three to five minutes. Succinylcholine is used in surgical, anesthetic, and other procedures in which a brief period of muscle relaxation is called for.

Molecular Formula

  • C14-H30-N2-O4

Molecular Weight

  • 290.401
 

Classification Codes

  • Drug / Therapeutic Agent
  • Human Data
  • Neuromuscular Agents
  • Neuromuscular Blocking Agents
  • Neuromuscular Depolarizing Agents
  • Peripheral Nervous System Agents

Names and Synonyms

Name of Substance

  • Succinylcholine

MeSH Heading

  • Succinylcholine

Synonyms

  • 4-04-00-01451 (Beilstein Handbook Reference)
  • BRN 1805311
  • Choline, succinate (2:1) (ester)
  • Choline, succinate (ester)
  • Choline, succinyl-
  • Diacetylcholine
  • Dicholine succinate
  • Ditilin
  • Ditiline
  • Ethanaminium, 2,2'-((1,4-dioxo-1,4-butanediyl)bis(oxy))bis(N,N,N-trimethyl-
  • HSDB 3254
  • Succinic acid, diester with choline
  • Succinocholine
  • Succinoylcholine
  • Succinyl choline
  • Succinylbischoline
  • Succinylcholine
  • Succinyldicholine
  • Suxamethonium
  • UNII-J2R869A8YF

Systematic Names

  • Choline, succinate (2:1) (ester)
  • Ethanaminium, 2,2'-((1,4-dioxo-1,4-butanediyl)bis(oxy))bis(N,N,N-trimethyl-

Registry Numbers

CAS Registry Number

  • 306-40-1

FDA UNII

  • J2R869A8YF

Related Registry Numbers

  • 541-19-5 (diiodide)
  • 55-94-7 (dibromide)
  • 71-27-2 (dichloride)

System Generated Number

  • 0000306401

Structure Descriptors

InChI

InChI=1S/C14H30N2O4/c1-15(2,3)9-11-19-13(17)7-8-14(18)20-12-10-16(4,5)6/h7-12H2,1-6H3/q+2

InChIKey

AXOIZCJOOAYSMI-UHFFFAOYSA-N

Smiles

C[N+](C)(C)CCOC(=O)CCC(=O)OCC[N+](C)(C)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intravenous 300ug/kg (0.3mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 88, Pg. 1, 1951.
human TDLo intravenous 1430ug/kg (1.43mg/kg) LUNGS, THORAX, OR RESPIRATION: STRUCTURAL OR FUNCTIONAL CHANGE IN TRACHEA OR BRONCHI Anaesthesist. Vol. 21, Pg. 27, 1972.
infant TDLo intravenous 1600ug/kg (1.6mg/kg) CARDIAC: OTHER CHANGES British Journal of Anesthesia. Vol. 58, Pg. 576, 1986.
mouse LD50 intraperitoneal 2140ug/kg (2.14mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 152, Pg. 277, 1964.
mouse LD50 intravenous 280ug/kg (0.28mg/kg)   Research Communications in Chemical Pathology and Pharmacology. Vol. 1, Pg. 141, 1970.
mouse LD50 oral 125mg/kg (125mg/kg)   "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. -, 1965.
mouse LD50 subcutaneous 7500ug/kg (7.5mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA		 Arzneimittel-Forschung. Drug Research. Vol. 15, Pg. 126, 1965.
rabbit LD50 intravenous 1mg/kg (1mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 88, Pg. 1, 1951.
rat LD50 subcutaneous 3400ug/kg (3.4mg/kg)   Pharmacology and Toxicology. English translation of FATOAO. Vol. 21, Pg. 473, 1958.
women TDLo unreported 1818ug/kg (1.818mg/kg) CARDIAC: OTHER CHANGES South African Medical Journal. Vol. 68, Pg. 601, 1985.