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Substance Name: Sapanisertib [USAN:INN]
RN: 1224844-38-5
UNII: JGH0DF1U03
InChIKey: GYLDXIAOMVERTK-UHFFFAOYSA-N

Notes

  • MTOR inhibitor drug.
  • NCI: TORC1/2 inhibitor MLN0128. An orally bioavailable inhibitor of raptor-mTOR (TOR complex 1 or TORC1) and rictor-mTOR (TOR complex 2 or TORC2) with potential antineoplastic activity. TORC1/2 inhibitor MLN0128 binds to and inhibits both TORC1 and TORC2 complexes of mTOR, which may result in tumor cell apoptosis and a decrease in tumor cell proliferation. TORC1 and 2 are upregulated in some tumors and play an important role in the PI3K/Akt/mTOR signaling pathway, which is frequently dysregulated in human cancers. (NCI Thesaurus)

Molecular Formula

  • C15-H15-N7-O

Molecular Weight

  • 309.3315
 

Classification Code

  • Treatment of Cancer
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Names and Synonyms

Name of Substance

  • MLN-0128
  • Sapanisertib [USAN:INN]

Synonyms

  • 2-Benzoxazolamine, 5-(4-amino-1-(1-methylethyl)-1H-pyrazolo(3,4-d)pyrimidin-3-yl)-
  • 3-(2-Amino-1,3-benzoxazol-5-yl)-1-isopropyl-1H-pyrazolo(3,4-d)pyrimidin-4-amine
  • INK 128
  • MLN-0128
  • MLN0128
  • Sapanisertib
  • TAK-228
  • UNII-JGH0DF1U03

Registry Numbers

CAS Registry Number

  • 1224844-38-5

FDA UNII

  • JGH0DF1U03

System Generated Number

  • 1224844385

Structure Descriptors

InChI

InChI=1S/C15H15N7O/c1-7(2)22-14-11(13(16)18-6-19-14)12(21-22)8-3-4-10-9(5-8)20-15(17)23-10/h3-7H,1-2H3,(H2,17,20)(H2,16,18,19)

InChIKey

GYLDXIAOMVERTK-UHFFFAOYSA-N

Smiles

CC(C)n1nc(c2ccc3oc(N)nc3c2)c4c(N)ncnc14