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Substance Name: Losartan [INN:BAN]
RN: 114798-26-4
UNII: JMS50MPO89
InChIKey: PSIFNNKUMBGKDQ-UHFFFAOYSA-N

Note

  • An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II.

Molecular Formula

  • C22-H23-Cl-N6-O

Molecular Weight

  • 422.9177
 

Classification Codes

  • Angiotensin II Type 1 Receptor Blockers
  • Angiotensin Receptor Antagonists
  • Anti-Arrhythmia Agents
  • Antihypertensive Agents
  • Cardiovascular Agents
  • Drug / Therapeutic Agent
  • Human Data

Names and Synonyms

Name of Substance

  • Losartan
  • Losartan [INN:BAN]

MeSH Heading

  • Losartan

Synonyms

  • 2-Butyl-4-chloro-1-((2'-(1H-etrazol-5-yl) (1,1'-biphenyl)-4-yl)methyl)-1H-imidazole-5-methanol
  • DUP 89
  • EC 601-329-8
  • HSDB 7043
  • Losartan
  • UNII-JMS50MPO89

Systematic Names

  • (1-((2'-(2H-Tetrazol-5-yl)biphenyl-4-yl)methyl)-2-butyl-4-chloro-1H-imidazol-5-yl)methanol
  • 1H-Imidazole-5-methanol, 2-butyl-4-chloro-1-((2'-(1H-tetrazol-5-yl)(1,1'- biphenyl)-4-yl)methyl)-

Mixture Name

  • Hyzaar

Registry Numbers

CAS Registry Number

  • 114798-26-4

FDA UNII

  • JMS50MPO89

Related Registry Number

  • 124750-99-8 (mono-potassium salt)

System Generated Number

  • 0114798264

Structure Descriptors

InChI

1S/C22H23ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,30H,2-3,8,13-14H2,1H3,(H,25,26,27,28)

InChIKey

PSIFNNKUMBGKDQ-UHFFFAOYSA-N

Smiles

CCCCc1nc(c(n1Cc2ccc(cc2)c3ccccc3c4[nH]nnn4)CO)Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo oral 7mg/kg/1W-I (7mg/kg) GASTROINTESTINAL: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: COUGH

SENSE ORGANS AND SPECIAL SENSES: CHANGE IN FUNCTION: TASTE
Annals of Internal Medicine. Vol. 129, Pg. 72, 1998.
man TDLo oral 17500ug/kg/17 (17.5mg/kg) SENSE ORGANS AND SPECIAL SENSES: CHANGE IN FUNCTION: TASTE Lancet. Vol. 347, Pg. 471, 1996.
man TDLo oral 18mg/kg/13W-I (18mg/kg) SENSE ORGANS AND SPECIAL SENSES: CHANGE IN FUNCTION: TASTE Annals of Internal Medicine. Vol. 129, Pg. 72, 1998.
man TDLo oral 21429ug/kg/30 (21.429mg/kg)   JAMA, Journal of the American Medical Association. Vol. 278, Pg. 1572, 1997.
man TDLo oral 21429ug/kg/30 (21.429mg/kg) LIVER: LIVER FUNCTION TESTS IMPAIRED

LIVER: OTHER CHANGES
JAMA, Journal of the American Medical Association. Vol. 278, Pg. 1572, 1997.
women TDLo oral 42mg/kg/6W-I (42mg/kg) KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"
Annals of Internal Medicine. Vol. 124, Pg. 775, 1996.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 184 deg C   EXP
pKa Dissociation Constant 5.5 (none)   EXP
log P (octanol-water) 4.010 (none)   EST
Atmospheric OH Rate Constant 5.09E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.