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Substance Name: Losartan [INN:BAN]
RN: 114798-26-4
UNII: JMS50MPO89
InChIKey: PSIFNNKUMBGKDQ-UHFFFAOYSA-N
Note
- An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II.
Molecular Formula
- C22-H23-Cl-N6-O
Molecular Weight
- 422.9177
- All
- Classifications
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- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Angiotensin II Type 1 Receptor Blockers
- Angiotensin Receptor Antagonists
- Anti-Arrhythmia Agents
- Antihypertensive Agents
- Antiviral (COVID-19)
- Cardiovascular Agents
- Drug / Therapeutic Agent
- Human Data
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Names and Synonyms
Name of Substance
- Losartan
- Losartan [INN:BAN]
MeSH Heading
- Losartan
Synonyms
- 2-Butyl-4-chloro-1-((2'-(1H-etrazol-5-yl) (1,1'-biphenyl)-4-yl)methyl)-1H-imidazole-5-methanol
- DUP 89
- EC 601-329-8
- HSDB 7043
- Losartan
- NSC 758699
- UNII-JMS50MPO89
Systematic Names
- (1-((2'-(2H-Tetrazol-5-yl)biphenyl-4-yl)methyl)-2-butyl-4-chloro-1H-imidazol-5-yl)methanol
- 1H-Imidazole-5-methanol, 2-butyl-4-chloro-1-((2'-(1H-tetrazol-5-yl)(1,1'- biphenyl)-4-yl)methyl)-
Mixture Name
- Hyzaar
Registry Numbers
CAS Registry Number
- 114798-26-4
FDA UNII
- JMS50MPO89
Related Registry Number
- 124750-99-8 (mono-potassium salt)
System Generated Number
- 0114798264
Structure Descriptors
InChI
InChI=1S/C22H23ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,30H,2-3,8,13-14H2,1H3,(H,25,26,27,28)InChIKey
PSIFNNKUMBGKDQ-UHFFFAOYSA-NSmiles
CCCCc1nc(Cl)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
man | TDLo | oral | 7mg/kg/1W-I (7mg/kg) | LUNGS, THORAX, OR RESPIRATION: COUGH GASTROINTESTINAL: OTHER CHANGES SENSE ORGANS AND SPECIAL SENSES: CHANGE IN FUNCTION: TASTE | Annals of Internal Medicine. Vol. 129, Pg. 72, 1998. |
man | TDLo | oral | 17500ug/kg/17 (17.5mg/kg) | SENSE ORGANS AND SPECIAL SENSES: CHANGE IN FUNCTION: TASTE | Lancet. Vol. 347, Pg. 471, 1996. |
man | TDLo | oral | 18mg/kg/13W-I (18mg/kg) | SENSE ORGANS AND SPECIAL SENSES: CHANGE IN FUNCTION: TASTE | Annals of Internal Medicine. Vol. 129, Pg. 72, 1998. |
man | TDLo | oral | 21429ug/kg/30 (21.429mg/kg) | LIVER: OTHER CHANGES LIVER: LIVER FUNCTION TESTS IMPAIRED | JAMA, Journal of the American Medical Association. Vol. 278, Pg. 1572, 1997. |
women | TDLo | oral | 42mg/kg/6W-I (42mg/kg) | KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" | Annals of Internal Medicine. Vol. 124, Pg. 775, 1996. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 184 | deg C | EXP | |
pKa Dissociation Constant | 5.5 | (none) | EXP | |
log P (octanol-water) | 4.010 | (none) | EST | |
Atmospheric OH Rate Constant | 5.09E-11 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.