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Substance Name: Refametinib [INN]
RN: 923032-37-5
UNII: JPX07AFM0N
InChIKey: RDSACQWTXKSHJT-NSHDSACASA-N

Note

  • A MEK inhibitor.

Molecular Formula

  • C19-H20-F3-I-N2-O5-S

Molecular Weight

  • 572.336
 
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Names and Synonyms

Name of Substance

  • Refametinib [INN]

Synonyms

  • BAY 86-9766
  • BAY 869766
  • BAY 8697661
  • RDEA 119
  • RDEA119
  • UNII-JPX07AFM0N

Systematic Name

  • Cyclopropanesulfonamide, N-(3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)-6-methoxyphenyl)-1-((2S)-2,3-dihydroxypropyl)-

Registry Numbers

CAS Registry Number

  • 923032-37-5

FDA UNII

  • JPX07AFM0N

System Generated Number

  • 0923032375

Structure Descriptors

InChI

InChI=1S/C19H20F3IN2O5S/c1-30-15-7-13(21)16(22)18(24-14-3-2-10(23)6-12(14)20)17(15)25-31(28,29)19(4-5-19)8-11(27)9-26/h2-3,6-7,11,24-27H,4-5,8-9H2,1H3/t11-/m0/s1

InChIKey

RDSACQWTXKSHJT-NSHDSACASA-N

Smiles

COc1cc(F)c(F)c(Nc2ccc(I)cc2F)c1NS(=O)(=O)C3(C[C@H](O)CO)CC3