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Substance Name: Phenazopyridine [INN:BAN]
RN: 94-78-0
UNII: K2J09EMJ52
InChIKey: QPFYXYFORQJZEC-FOCLMDBBSA-N
Note
- A local anesthetic that has been used in urinary tract disorders. Its use is limited by problems with toxicity (primarily blood disorders) and potential carcinogenicity.
Molecular Formula
- C11-H11-N5
Molecular Weight
- 213.2429
- All
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- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Drug / Therapeutic Agent
- Tumor Data
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Names and Synonyms
Name of Substance
- Phenazopyridine
- Phenazopyridine [INN:BAN]
MeSH Heading
- Phenazopyridine
Synonyms
- 2,6-Diamino-3-phenylazopyridine
- 2,6-Pyridinediamine, 3-(phenylazo)-
- 3-(Phenylazo)-2,6-pyridinediamine
- 5-22-14-00711 (Beilstein Handbook Reference)
- Baridium
- BRN 0184497
- EINECS 202-363-2
- Eridium
- Fenazopiridina
- Fenazopiridina [INN-Spanish]
- Gastracid
- Gastrotest
- Geridium
- HSDB 3153
- NSC 145895
- Phenazopyridine
- Phenazopyridinum
- Phenazopyridinum [INN-Latin]
- Pyrazofen
- Pyridiate
- UNII-K2J09EMJ52
- Urogesic
- Viridium
Systematic Names
- 2,6-Pyridinediamine, 3-(phenylazo)-
- 2,6-Pyridinediamine, 3-(phenylazo)- (9CI)
- Phenazopyridine
- Pyridine, 2,6-diamino-3-(phenylazo)-
Superlist Names
- 2,6-Pyridinediamine, 3-(phenylazo)-
- Phenazopyridine
Registry Numbers
CAS Registry Number
- 94-78-0
FDA UNII
- K2J09EMJ52
System Generated Number
- 0000094780
Structure Descriptors
InChI
InChI=1S/C11H11N5/c12-10-7-6-9(11(13)14-10)16-15-8-4-2-1-3-5-8/h1-7H,(H4,12,13,14)/b16-15+InChIKey
QPFYXYFORQJZEC-FOCLMDBBSA-NSmiles
Nc1ccc(\N=N\c2ccccc2)Toxicity
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| man | TDLo | oral | 4693mg/kg/3Y- (4693mg/kg) | BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN KIDNEY, URETER, AND BLADDER: OTHER CHANGES IN URINE COMPOSITION SKIN AND APPENDAGES (SKIN): NAILS: OTHER | Annals of Internal Medicine. Vol. 127, Pg. 1137, 1997. |
| mouse | LD50 | oral | 580mg/kg (580mg/kg) | Pharmaceutica Acta Helvetiae. Vol. 35, Pg. 423, 1960. | |
| rat | LD50 | intraperitoneal | 560mg/kg (560mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA LUNGS, THORAX, OR RESPIRATION: STRUCTURAL OR FUNCTIONAL CHANGE IN TRACHEA OR BRONCHI BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Journal of Pharmacology and Experimental Therapeutics. Vol. 51, Pg. 200, 1934. |
Physical Properties
| Physical Property | Value | Units | Temp (deg C) | Source |
|---|---|---|---|---|
| Melting Point | 139 | deg C | EXP | |
| log P (octanol-water) | 2.770 | (none) | EST | |
| Water Solubility | 388 | mg/L | 25 | EST |
| Vapor Pressure | 9.60E-07 | mm Hg | 25 | EST |
| Henry's Law Constant | 3.30E-15 | atm-m3/mole | 25 | EST |
| Atmospheric OH Rate Constant | 2.00E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.