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Substance Name: Trimetrexate glucuronate [USAN]
RN: 82952-64-5
UNII: L137U4A79K
InChIKey: ZCJXQWYMBJYJNB-LRDBBFHQSA-N
Notes
- A nonclassical folic acid inhibitor through its inhibition of the enzyme dihydrofolate reductase. It is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against PNEUMOCYSTIS PNEUMONIA in AIDS patients. Myelosuppression is its dose-limiting toxic effect.
- An orphan drug and AIDS drug; used for treatment of Pneumocytis carinii pneumonia in patients with AIDS.
Molecular Formula
- C19-H23-N5-O3.C6-H10-O7
Molecular Weight
- 563.5607
- All
- Classifications
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- Registry Numbers
- Formulas
- Structure Descriptors
- Toxicity
Classification Codes
- Antineoplastic
- Drug / Therapeutic Agent
- Human Data
- Mutation Data
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Names and Synonyms
Name of Substance
- Trimetrexate D-glucuronate
- Trimetrexate glucuronate
- Trimetrexate glucuronate [USAN]
Synonyms
- 2,4-Diamino-5-methyl-6-((3,4,5-trimethoxyanilino)methyl)quinazoline mono-D-glucuronate
- 2,4-Quinazolinediamine, 5-methyl-6-(((3,4,5-trimethoxyphenyl)amino)methyl)-, mono-D-glucuronate
- 6-(((3,4,5-Trimethoxyphenyl)amino)methyl)-5-methyl-2,4-quinazolinediamine glucuronate
- CI 898
- DRG-0183
- Neutrexin
- Trimetrexate glucuronate
- Trimetrexate glucuronic acid salt
- UNII-L137U4A79K
Systematic Names
- 2,4-Quinazolinediamine, 5-methyl-6-(((3,4,5-trimethoxyphenyl)amino)methyl)-, mono-D-glucuronate
- D-Glucuronic acid, compd. with 5-methyl-6-(((3,4,5-trimethoxyphenyl)amino)methyl)-2,4-quinazolinediamine (1:1)
Superlist Name
- Trimetrexate glucuronate
Registry Numbers
CAS Registry Number
- 82952-64-5
FDA UNII
- L137U4A79K
System Generated Number
- 0082952645
Molecular Formulas
Molecular Formula
- C19-H23-N5-O3.C6-H10-O7
Molecular Formula Fragments
- C19-H23-N5-O3
- C6-H10-O7
- COMPONENT
Structure Descriptors
InChI
InChI=1S/C19H23N5O3.C6H10O7/c1-10-11(5-6-13-16(10)18(20)24-19(21)23-13)9-22-12-7-14(25-2)17(27-4)15(8-12)26-3;7-1-2(8)3(9)4(10)5(11)6(12)13/h5-8,22H,9H2,1-4H3,(H4,20,21,23,24);1-5,8-11H,(H,12,13)/t;2-,3+,4-,5-/m.0/s1InChIKey
ZCJXQWYMBJYJNB-LRDBBFHQSA-NSmiles
COc1cc(NCc2ccc3nc(N)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
human | LDLo | intravenous | 2027ug/kg (2.027mg/kg) | VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION GASTROINTESTINAL: OTHER CHANGES BLOOD: THROMBOCYTOPENIA | Cancer Research. Vol. 47, Pg. 3303, 1987. |
human | TDLo | intravenous | 4054mg/kg/3W- (4054mg/kg) | BLOOD: CHANGES IN BONE MARROW NOT INCLUDED ABOVE | Cancer Research. Vol. 47, Pg. 3303, 1987. |
rat | LDLo | intravenous | 60mg/kg (60mg/kg) | Fundamental and Applied Toxicology. Vol. 18, Pg. 115, 1992. |