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Substance Name: Methyl salicylate [JAN:NF]
RN: 119-36-8
UNII: LAV5U5022Y
InChIKey: OSWPMRLSEDHDFF-UHFFFAOYSA-N

Note

  • Used in over-the-counter liniments, ointments, lotions for relief of musculoskeletal aches and pains; has hemolytic effect on human & sheep erythrocytes.

Molecular Formula

  • C8-H8-O3

Molecular Weight

  • 152.1482
 

Classification Codes

  • Antirheumatic Agents
  • Fixatives
  • Human Data
  • Mutation Data
  • Pharmaceutic Aid (Flavor)
  • Reproductive Effect
  • Skin / Eye Irritant

Names and Synonyms

Name of Substance

  • 2-Hydroxybenzoic acid, methyl ester
  • Benzoic acid, 2-hydroxy-, methyl ester
  • Birch oil, sweet
  • Methyl 2-hydroxybenzoate
  • Methyl salicylate
  • Methyl salicylate [JAN:NF]
  • Oil of wintergreen
  • Sweet birch oil

Synonyms

  • 2-(Methoxycarbonyl)phenol
  • 2-Carbomethoxyphenol
  • 2-Hydroxybenzoic acid methyl ester
  • 4-10-00-00143 (Beilstein Handbook Reference)
  • AI3-00090
  • Analgit
  • Anthrapole ND
  • Ben Gay
  • Benzoic acid, 2-hydroxy-, methyl ester
  • Betula
  • Betula Lenta
  • Betula oil
  • BRN 0971516
  • Caswell No. 577
  • CCRIS 6259
  • EC 204-317-7
  • EINECS 204-317-7
  • EPA Pesticide Chemical Code 076601
  • Exagien
  • FEMA No. 2745
  • FEMA Number 2745
  • Flucarmit
  • Gaultheria oil
  • Gaultheria oil, artificial
  • Gaultheriaoel
  • HSDB 1935
  • Methyl 2-hydroxybenzoate
  • Methyl o-hydroxybenzoate
  • Methyl salicylate
  • Methyl salicylate (natural)
  • Methylester kyseliny salicylove
  • Methylester kyseliny salicylove [Czech]
  • Metylester kyseliny salicylove
  • Metylester kyseliny salicylove [Czech]
  • Natural wintergreen oil
  • NSC 8204
  • o-Anisic acid
  • o-Hydroxybenzoic acid, methyl ester
  • Oil of wintergreen
  • PredaLure
  • Salicylic acid, methyl ester
  • Spicewood Oil
  • Sweet birch oil
  • Synthetic wintergreen oil
  • Teaberry oil
  • UNII-LAV5U5022Y
  • Wintergreen oil
  • Wintergreen oil, synthetic
  • Wintergruenoel

Systematic Names

  • Benzoic acid, 2-hydroxy-, methyl ester
  • Methyl salicylate
  • Salicylic acid, methyl ester

Superlist Names

  • Benzoic acid, 2-hydroxy-, methyl ester
  • Methyl salicylate
  • Salicylic acid, methyl ester

Mixture Names

  • Heet
  • Panalgesic
  • Salonpas
  • Theragesic

Registry Numbers

CAS Registry Number

  • 119-36-8

FDA UNII

  • LAV5U5022Y

Other Registry Numbers

  • 648434-07-5
  • 8022-86-4
  • 8024-54-2

Related Registry Number

  • 7631-93-8 (hydrochloride salt)

System Generated Number

  • 0000119368

Structure Descriptors

InChI

InChI=1S/C8H8O3/c1-11-8(10)6-4-2-3-5-7(6)9/h2-5,9H,1H3

InChIKey

OSWPMRLSEDHDFF-UHFFFAOYSA-N

Smiles

COC(=O)c1ccccc1O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child LDLo oral 228mg/kg (228mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

LUNGS, THORAX, OR RESPIRATION: DYSPNEA		 American Journal of Diseases of Children. Vol. 69, Pg. 37, 1945.
child LDLo oral 700mg/kg (700mg/kg) BEHAVIORAL: GENERAL ANESTHETIC

PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA		 Archives of Disease in Childhood. Vol. 28, Pg. 475, 1953.
dog LD50 oral 2100mg/kg (2100mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES		 Food and Cosmetics Toxicology. Vol. 16, Pg. 821, 1978.
dog LDLo subcutaneous 2250mg/kg (2250mg/kg)   Food and Cosmetics Toxicology. Vol. 16, Pg. 821, 1978.
guinea pig LD50 oral 700mg/kg (700mg/kg)   "Industrial Hygiene and Toxicology," 2nd ed., Patty, F.A., ed., New York, John Wiley & Sons, Inc., 1958-63Vol. 2, Pg. 1897, 1963.
guinea pig LDLo subcutaneous 1500mg/kg (1500mg/kg)   FAO Nutrition Meetings Report Series. Vol. 44A, Pg. 63, 1967.
human LDLo oral 506mg/kg (506mg/kg)   "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989Vol. 11, Pg. 961, 1989.
infant LDLo oral 1480mg/kg (1480mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

GASTROINTESTINAL: NAUSEA OR VOMITING		 American Journal of the Medical Sciences. Vol. 193, Pg. 772, 1937.
man LDLo oral 101mg/kg (101mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

GASTROINTESTINAL: NAUSEA OR VOMITING		 American Journal of the Medical Sciences. Vol. 193, Pg. 772, 1937.
man LDLo oral 1329mg/kg (1329mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: COMA

BLOOD: HEMORRHAGE		 Clinical Toxicology. Vol. 6, Pg. 189, 1973.
man LDLo unreported 522mg/kg (522mg/kg)   "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970.
mouse LD50 oral 1110mg/kg (1110mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 132, Pg. 207, 1961.
rabbit LD50 oral 1300mg/kg (1300mg/kg)   Food and Cosmetics Toxicology. Vol. 16, Pg. 821, 1978.
rabbit LDLo subcutaneous 4250mg/kg (4250mg/kg)   Food and Cosmetics Toxicology. Vol. 16, Pg. 821, 1978.
rat LD50 oral 887mg/kg (887mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Food and Cosmetics Toxicology. Vol. 2, Pg. 327, 1964.
women LDLo oral 355mg/kg (355mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

GASTROINTESTINAL: NAUSEA OR VOMITING

BEHAVIORAL: COMA		 American Journal of the Medical Sciences. Vol. 193, Pg. 772, 1937.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point -8.00E+00 deg C   EXP
Boiling Point 222.9 deg C   EXP
pKa Dissociation Constant 9.87 (none) 20 EXP
log P (octanol-water) 2.55 (none)   EXP
Water Solubility 700 mg/L 30 EXP
Vapor Pressure 0.0343 mm Hg 25 EXP
Henry's Law Constant 9.81E-05 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.11E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.