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Substance Name: Methyl salicylate [JAN:NF]
RN: 119-36-8
UNII: LAV5U5022Y
InChIKey: OSWPMRLSEDHDFF-UHFFFAOYSA-N
Note
- Used in over-the-counter liniments, ointments, lotions for relief of musculoskeletal aches and pains; has hemolytic effect on human & sheep erythrocytes.
Molecular Formula
- C8-H8-O3
Molecular Weight
- 152.1482
- All
- Classifications
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- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Antirheumatic Agents
- Fixatives
- Human Data
- Mutation Data
- Pharmaceutic Aid (Flavor)
- Reproductive Effect
- Skin / Eye Irritant
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Names and Synonyms
Name of Substance
- 2-Hydroxybenzoic acid, methyl ester
- Benzoic acid, 2-hydroxy-, methyl ester
- Birch oil, sweet
- Methyl 2-hydroxybenzoate
- Methyl salicylate
- Methyl salicylate [JAN:NF]
- Oil of wintergreen
- Sweet birch oil
Synonyms
- 2-(Methoxycarbonyl)phenol
- 2-Carbomethoxyphenol
- 2-Hydroxybenzoic acid methyl ester
- 4-10-00-00143 (Beilstein Handbook Reference)
- AI3-00090
- Analgit
- Anthrapole ND
- Ben Gay
- Benzoic acid, 2-hydroxy-, methyl ester
- Betula
- Betula Lenta
- Betula oil
- BRN 0971516
- Caswell No. 577
- CCRIS 6259
- EC 204-317-7
- EINECS 204-317-7
- EPA Pesticide Chemical Code 076601
- Exagien
- FEMA No. 2745
- FEMA Number 2745
- Flucarmit
- Gaultheria oil
- Gaultheria oil, artificial
- Gaultheriaoel
- HSDB 1935
- Methyl 2-hydroxybenzoate
- Methyl o-hydroxybenzoate
- Methyl salicylate
- Methyl salicylate (natural)
- Methylester kyseliny salicylove
- Methylester kyseliny salicylove [Czech]
- Metylester kyseliny salicylove
- Metylester kyseliny salicylove [Czech]
- Natural wintergreen oil
- NSC 8204
- o-Anisic acid
- o-Hydroxybenzoic acid, methyl ester
- Oil of wintergreen
- PredaLure
- Salicylic acid, methyl ester
- Spicewood Oil
- Sweet birch oil
- Synthetic wintergreen oil
- Teaberry oil
- UNII-LAV5U5022Y
- Wintergreen oil
- Wintergreen oil, synthetic
- Wintergruenoel
Systematic Names
- Benzoic acid, 2-hydroxy-, methyl ester
- Methyl salicylate
- Salicylic acid, methyl ester
Superlist Names
- Benzoic acid, 2-hydroxy-, methyl ester
- Methyl salicylate
- Salicylic acid, methyl ester
Mixture Names
- Heet
- Panalgesic
- Salonpas
- Theragesic
Registry Numbers
CAS Registry Number
- 119-36-8
FDA UNII
- LAV5U5022Y
Other Registry Numbers
- 648434-07-5
- 8022-86-4
- 8024-54-2
Related Registry Number
- 7631-93-8 (hydrochloride salt)
System Generated Number
- 0000119368
Structure Descriptors
InChI
InChI=1S/C8H8O3/c1-11-8(10)6-4-2-3-5-7(6)9/h2-5,9H,1H3InChIKey
OSWPMRLSEDHDFF-UHFFFAOYSA-NSmiles
COC(=O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
child | LDLo | oral | 228mg/kg (228mg/kg) | GASTROINTESTINAL: NAUSEA OR VOMITING LUNGS, THORAX, OR RESPIRATION: DYSPNEA | American Journal of Diseases of Children. Vol. 69, Pg. 37, 1945. |
child | LDLo | oral | 700mg/kg (700mg/kg) | BEHAVIORAL: GENERAL ANESTHETIC PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Archives of Disease in Childhood. Vol. 28, Pg. 475, 1953. |
dog | LD50 | oral | 2100mg/kg (2100mg/kg) | GASTROINTESTINAL: NAUSEA OR VOMITING GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Food and Cosmetics Toxicology. Vol. 16, Pg. 821, 1978. |
dog | LDLo | subcutaneous | 2250mg/kg (2250mg/kg) | Food and Cosmetics Toxicology. Vol. 16, Pg. 821, 1978. | |
guinea pig | LD50 | oral | 700mg/kg (700mg/kg) | "Industrial Hygiene and Toxicology," 2nd ed., Patty, F.A., ed., New York, John Wiley & Sons, Inc., 1958-63Vol. 2, Pg. 1897, 1963. | |
guinea pig | LDLo | subcutaneous | 1500mg/kg (1500mg/kg) | FAO Nutrition Meetings Report Series. Vol. 44A, Pg. 63, 1967. | |
human | LDLo | oral | 506mg/kg (506mg/kg) | "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989Vol. 11, Pg. 961, 1989. | |
infant | LDLo | oral | 1480mg/kg (1480mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION GASTROINTESTINAL: NAUSEA OR VOMITING | American Journal of the Medical Sciences. Vol. 193, Pg. 772, 1937. |
man | LDLo | oral | 101mg/kg (101mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: NAUSEA OR VOMITING | American Journal of the Medical Sciences. Vol. 193, Pg. 772, 1937. |
man | LDLo | oral | 1329mg/kg (1329mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: COMA BLOOD: HEMORRHAGE | Clinical Toxicology. Vol. 6, Pg. 189, 1973. |
man | LDLo | unreported | 522mg/kg (522mg/kg) | "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970. | |
mouse | LD50 | oral | 1110mg/kg (1110mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 132, Pg. 207, 1961. | |
rabbit | LD50 | oral | 1300mg/kg (1300mg/kg) | Food and Cosmetics Toxicology. Vol. 16, Pg. 821, 1978. | |
rabbit | LDLo | subcutaneous | 4250mg/kg (4250mg/kg) | Food and Cosmetics Toxicology. Vol. 16, Pg. 821, 1978. | |
rat | LD50 | oral | 887mg/kg (887mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Food and Cosmetics Toxicology. Vol. 2, Pg. 327, 1964. |
women | LDLo | oral | 355mg/kg (355mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION GASTROINTESTINAL: NAUSEA OR VOMITING BEHAVIORAL: COMA | American Journal of the Medical Sciences. Vol. 193, Pg. 772, 1937. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | -8.00E+00 | deg C | EXP | |
Boiling Point | 222.9 | deg C | EXP | |
pKa Dissociation Constant | 9.87 | (none) | 20 | EXP |
log P (octanol-water) | 2.55 | (none) | EXP | |
Water Solubility | 700 | mg/L | 30 | EXP |
Vapor Pressure | 0.0343 | mm Hg | 25 | EXP |
Henry's Law Constant | 9.81E-05 | atm-m3/mole | 25 | EST |
Atmospheric OH Rate Constant | 1.11E-11 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.