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Substance Name: Nabumetone [USAN:USP:INN:BAN:JAN]
RN: 42924-53-8
UNII: LW0TIW155Z
InChIKey: BLXXJMDCKKHMKV-UHFFFAOYSA-N
Note
- A butanone non-steroidal anti-inflammatory drug and cyclooxygenase-2 (COX2) inhibitor that is used in the management of pain associated with OSTEOARTHRITIS and RHEUMATOID ARTHRITIS.
Molecular Formula
- C15-H16-O2
Molecular Weight
- 228.289
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Analgesic
- Analgesics
- Analgesics, Non-Narcotic
- Anti-Inflammatory
- Anti-Inflammatory Agents
- Anti-Inflammatory Agents, Non-Steroidal
- Antirheumatic Agents
- Cyclooxygenase 2 Inhibitors
- Cyclooxygenase Inhibitors
- Drug / Therapeutic Agent
- Enzyme Inhibitors
- Human Data
- Peripheral Nervous System Agents
- Reproductive Effect
- Sensory System Agents
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Links to Resources
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Names and Synonyms
Name of Substance
- Nabumetone
- Nabumetone [USAN:USP:INN:BAN:JAN]
MeSH Heading
- Nabumetone
Synonyms
- 4-(6-Methoxy-2-naphthalenyl)-2-butanone
- 4-(6-Methoxy-2-naphthyl)-2-butanone
- Arthaxan
- Balmox
- BRL 14777
- BRN 2103472
- CCRIS 8108
- Consolan
- Dolsinal
- Flambate
- Listran
- Mebutan
- Nabumetona
- Nabumetone
- Nabumetonum
- Nabumetonum [INN-Latin]
- Prodac
- Relafen
- Relif
- Relifen
- Relifex
- UNII-LW0TIW155Z
- Unimetone
Systematic Name
- 2-Butanone, 4-(6-methoxy-2-naphthalenyl)-
Registry Numbers
CAS Registry Number
- 42924-53-8
FDA UNII
- LW0TIW155Z
System Generated Number
- 0042924538
Structure Descriptors
InChI
InChI=1S/C15H16O2/c1-11(16)3-4-12-5-6-14-10-15(17-2)8-7-13(14)9-12/h5-10H,3-4H2,1-2H3InChIKey
BLXXJMDCKKHMKV-UHFFFAOYSA-NSmiles
COc1ccc2cc(CCC(=O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
monkey | LD50 | oral | 3200mg/kg (3200mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 22, Pg. 2939, 1988. | |
monkey | LD50 | oral | 3200mg/kg (3200mg/kg) | GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS | Kiso to Rinsho. Clinical Report. Vol. 22, Pg. 2939, 1988. |
mouse | LD50 | intraperitoneal | 2380mg/kg (2380mg/kg) | GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Kiso to Rinsho. Clinical Report. Vol. 22, Pg. 2939, 1988. |
mouse | LD50 | oral | 4290mg/kg (4290mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: OTHER CHANGES BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) | Kiso to Rinsho. Clinical Report. Vol. 22, Pg. 2939, 1988. |
mouse | LD50 | subcutaneous | > 10gm/kg (10000mg/kg) | SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" | Kiso to Rinsho. Clinical Report. Vol. 22, Pg. 2939, 1988. |
rat | LD50 | intraperitoneal | 1520mg/kg (1520mg/kg) | GASTROINTESTINAL: OTHER CHANGES SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH | Kiso to Rinsho. Clinical Report. Vol. 22, Pg. 2939, 1988. |
rat | LD50 | oral | 3880mg/kg (3880mg/kg) | GASTROINTESTINAL: OTHER CHANGES GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH | Kiso to Rinsho. Clinical Report. Vol. 22, Pg. 2939, 1988. |
rat | LD50 | subcutaneous | > 10gm/kg (10000mg/kg) | SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" | Kiso to Rinsho. Clinical Report. Vol. 22, Pg. 2939, 1988. |
women | TDLo | oral | 1260mg/kg/6W- (1260mg/kg) | LUNGS, THORAX, OR RESPIRATION: FIBROSIS (INTERSTITIAL) LUNGS, THORAX, OR RESPIRATION: COUGH LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Postgraduate Medical Journal. Vol. 67, Pg. 1021, 1991. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
log P (octanol-water) | 3.08 | (none) | EXP | |
Water Solubility | 72.8 | mg/L | 25 | EST |
Vapor Pressure | 2.02E-05 | mm Hg | 25 | EST |
Henry's Law Constant | 3.07E-08 | atm-m3/mole | 25 | EST |
Atmospheric OH Rate Constant | 1.22E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.