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Substance Name: Ibudilast [INN:JAN]
RN: 50847-11-5
UNII: M0TTH61XC5
InChIKey: ZJVFLBOZORBYFE-UHFFFAOYSA-N

Molecular Formula

  • C14-H18-N2-O

Molecular Weight

  • 230.3092
 

Classification Codes

  • Anti-Asthmatic Agents
  • Antiviral (COVID-19)
  • Autonomic Agents
  • Bronchodilator Agents
  • Cardiovascular Agents
  • Drug / Therapeutic Agent
  • Enzyme Inhibitors
  • Hematologic Agents
  • Peripheral Nervous System Agents
  • Phosphodiesterase Inhibitors
  • Platelet Aggregation Inhibitors
  • Reproductive Effect
  • Respiratory System Agents
  • Vasodilator Agents
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Names and Synonyms

Name of Substance

  • Ibudilast
  • Ibudilast [INN:JAN]

Synonyms

  • 1-(2-Isopropylpyrazolo(1,5-a)pyridin-3-yl)-2-methyl-1-propanone
  • 1-Propanone, 2-methyl-1-(2-(1-methylethyl)pyrazolo(1,5-a)pyridin-3-yl)-
  • 2-Isopropyl-3-isobutyrylpyrazolo(1,5-a)pyridine
  • 3-Isobutyryl-2-isopropylpyrazolo(1,5-a)pyridine
  • 5-24-03-00396 (Beilstein Handbook Reference)
  • AV 411
  • AV411
  • BRN 0656579
  • Ibudilast
  • Ibudilastum
  • Ibudilastum [Latin]
  • KC-404
  • Ke Tas
  • Ketas
  • MN-166
  • UNII-M0TTH61XC5

Systematic Names

  • 1-(2-Isopropylpyrazolo(1,5-a)pyridin-3-yl)-2-methyl-1-propanone
  • Pyrazolo(1,5-a)pyridine, 3-isobutyryl-2-isopropyl-

Registry Numbers

CAS Registry Number

  • 50847-11-5

FDA UNII

  • M0TTH61XC5

System Generated Number

  • 0050847115

Structure Descriptors

InChI

InChI=1S/C14H18N2O/c1-9(2)13-12(14(17)10(3)4)11-7-5-6-8-16(11)15-13/h5-10H,1-4H3

InChIKey

ZJVFLBOZORBYFE-UHFFFAOYSA-N

Smiles

CC(C)C(=O)c1c(nn2ccccc12)C(C)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 460mg/kg (460mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 5503, 1985.
mouse LD50 intravenous 146mg/kg (146mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: TREMOR
Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 5503, 1985.
mouse LD50 oral 1860mg/kg (1860mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 5503, 1985.
mouse LD50 subcutaneous 3100mg/kg (3100mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 5503, 1985.
rat LD50 intraperitoneal 419mg/kg (419mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 5503, 1985.
rat LD50 intravenous 42500ug/kg (42.5mg/kg) KIDNEY, URETER, AND BLADDER: HEMATURIA

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 5503, 1985.
rat LD50 oral 1340mg/kg (1340mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 5503, 1985.
rat LD50 subcutaneous 1300mg/kg (1300mg/kg) KIDNEY, URETER, AND BLADDER: HEMATURIA Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 5503, 1985.