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Substance Name: Magnesium sulfate anhydrous
RN: 7487-88-9
UNII: ML30MJ2U7I
InChIKey: CSNNHWWHGAXBCP-UHFFFAOYSA-L
Note
- A small colorless crystal used as an anticonvulsant, a cathartic, and an electrolyte replenisher in the treatment of pre-eclampsia and eclampsia. It causes direct inhibition of action potentials in myometrial muscle cells. Excitation and contraction are uncoupled, which decreases the frequency and force of contractions. (From AMA Drug Evaluations Annual, 1992, p1083).
Molecular Formulas
- H2-O4-S.Mg
- O4-S.Mg
Molecular Weight
- 120.367
- All
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Classification Codes
- Analgesics
- Anesthetics
- Anti-Arrhythmia Agents
- Anticonvulsants
- Calcium Channel Blockers
- Calcium-Regulating Hormones and Agents
- Cardiovascular Agents
- Central Nervous System Agents
- Central Nervous System Depressants
- Drug / Therapeutic Agent
- Human Data
- Membrane Transport Modulators
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- Peripheral Nervous System Agents
- Reproductive Control Agents
- Reproductive Effect
- Sensory System Agents
- Tocolytic Agents
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Names and Synonyms
Name of Substance
- Magnesium sulfate
- Magnesium sulfate anhydrous
- Sulfuric acid, magnesium salt (1:1)
MeSH Heading
- Magnesium sulfate
Synonyms
- Arrosalt 2327
- Caswell No. 534
- CCRIS 8411
- EC 231-298-2
- EINECS 231-298-2
- EPA Pesticide Chemical Code 050503
- Epsom salt
- Epsom salts
- HSDB 664
- Magnesii sulfas
- Magnesium sulfate
- Magnesium sulfate (1:1)
- Magnesium sulfate in dextrose 5% in plastic container
- Magnesium sulfate in plastic container
- Magnesium sulphate
- NSC 146179
- OT-S
- OT-S (drying agent)
- Sal Angalis
- Sal De sedlitz
- SN 00
- Sulfato de magnesio
- Sulfuric acid magnesium salt
- Sulfuric acid magnesium salt (1:1)
- Sulfuric acid magnesium salt (VAN)
- Tomix OT
- UNII-ML30MJ2U7I
Systematic Names
- Magnesium sulfate (1:1)
- Magnesium sulphate
- Sulfuric acid magnesium salt (1:1)
Superlist Name
- Magnesium sulfate
Registry Numbers
CAS Registry Number
- 7487-88-9
FDA UNII
- ML30MJ2U7I
Other Registry Numbers
- 139939-75-6
- 849607-35-8
Related Registry Number
- 10034-99-8 (heptahydrate)
System Generated Number
- 0007487889
Molecular Formulas
Molecular Formulas
- H2-O4-S.Mg
- O4-S.Mg
Molecular Formula Fragments
- COMPONENT
- H2-O4-S
- Mg
- O4-S
Structure Descriptors
InChI
InChI=1S/Mg.H2O4S/c;1-5(2,3)4/h;(H2,1,2,3,4)/q+2;/p-2InChIKey
CSNNHWWHGAXBCP-UHFFFAOYSA-LSmiles
[Mg+2].[O-]S(=O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
cat | LDLo | subcutaneous | 1gm/kg (1000mg/kg) | BEHAVIORAL: GENERAL ANESTHETIC | American Journal of Physiology. Vol. 14, Pg. 366, 1905. |
dog | LDLo | intraperitoneal | 1200mg/kg (1200mg/kg) | "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1364, 1935. | |
dog | LDLo | subcutaneous | 1500mg/kg (1500mg/kg) | "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1364, 1935. | |
guinea pig | LDLo | subcutaneous | 1800mg/kg (1800mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: GENERAL ANESTHETIC | American Journal of Physiology. Vol. 14, Pg. 366, 1905. |
man | TDLo | oral | 428mg/kg (428mg/kg) | BEHAVIORAL: MUSCLE WEAKNESS LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Japanese Journal of Toxicology. Vol. 2, Pg. 285, 1989. |
mouse | LD50 | intraperitoneal | 1029mg/kg (1029mg/kg) | Farmakologiya i Toksikologiya Vol. 10, Pg. 107, 1975. | |
mouse | LD50 | subcutaneous | 645mg/kg (645mg/kg) | Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. Vol. 7, Pg. 178, 1986. | |
mouse | LDLo | intravenous | 48mg/kg (48mg/kg) | Toxicology and Applied Pharmacology. Vol. 4, Pg. 492, 1962. | |
mouse | LDLo | oral | 5gm/kg (5000mg/kg) | "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1364, 1935. | |
rabbit | LDLo | oral | 3gm/kg (3000mg/kg) | "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1364, 1935. | |
rabbit | LDLo | subcutaneous | 1750mg/kg (1750mg/kg) | LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | American Journal of Physiology. Vol. 14, Pg. 366, 1905. |
rat | LD50 | subcutaneous | 1200mg/kg (1200mg/kg) | Neuroscience Letters. Vol. 117, Pg. 207, 1990. | |
women | LDLo | intravenous | 80mg/kg/2M-I (80mg/kg) | CARDIAC: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: CYANOSIS | South African Medical Journal. Vol. 67, Pg. 145, 1985. |
women | TDLo | intraspinal | 20mg/kg (20mg/kg) | PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITH APPROPRIATE ANESTHESIA | South African Medical Journal. Vol. 68, Pg. 367, 1985. |
women | TDLo | oral | 351mg/kg (351mg/kg) | BLOOD: "CHANGES IN SERUM COMPOSITION (E.G., TP, BILIRUBIN, CHOLESTEROL)" BEHAVIORAL: MUSCLE WEAKNESS CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) | Journal of Toxicology, Clinical Toxicology. Vol. 34, Pg. 735, 1996. |