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Substance Name: Clonidine [USAN:USP:INN:BAN]
RN: 4205-90-7
UNII: MN3L5RMN02
InChIKey: GJSURZIOUXUGAL-UHFFFAOYSA-N
Note
- An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
Molecular Formula
- C9-H9-Cl2-N3
Molecular Weight
- 230.097
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Adrenergic Agents
- Adrenergic Agonists
- Adrenergic alpha-2 Receptor Agonists
- Adrenergic alpha-Agonists
- Analgesics
- Antihypertensive
- Antihypertensive Agents
- Autonomic Agents
- Cardiovascular Agents
- Central Nervous System Agents
- Drug / Therapeutic Agent
- Human Data
- Neurotransmitter Agents
- Peripheral Nervous System Agents
- Reproductive Effect
- Sensory System Agents
- Skin / Eye Irritant
- Sympatholytics
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Links to Resources
NLM Resources (File Locators)
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Names and Synonyms
Name of Substance
- Clonidine
- Clonidine [USAN:USP:INN:BAN]
MeSH Heading
- Clonidine
Synonyms
- 1H-Imidazol-2-amine, N-(2,6-dichlorophenyl)-4,5-dihydro-
- 2,6-Dichloro-N-2-imidazolidinylidenebenzenamine
- 2-((2,6-Dichlorophenyl)imino)imidazolidine
- 2-(2,6-Dichloroanilino)-1,3-diazacyclopentene-(2)
- 2-(2,6-Dichloroanilino)-2-imidazoline
- 2-(2,6-Dichlorophenylamino)-2-imidazoline
- 734571A
- Adesipress
- Benzenamine, 2,6-dichloro-N-2-imidazolidinylidene-
- Catapres
- Catapres- TTS
- Catapres-TTS
- Catapres-TTS-1
- Catapres-TTS-2
- Catapres-TTS-3
- Catarpres
- Catarpresan
- CCRIS 7787
- Chlornidinum
- Clonidin
- Clonidina
- Clonidina [INN-Spanish]
- Clonidine
- Clonidinum
- Clonidinum [INN-Latin]
- Duraclon
- EINECS 224-119-4
- HSDB 3040
- M-5041T
- Nexiclon XR
- SKF 34427
- ST 155BS
- ST-155-BS
- UNII-MN3L5RMN02
Systematic Names
- 1H-Imidazol-2-amine, N-(2,6-dichlorophenyl)-4,5-dihydro-
- 2-Imidazoline, 2-(2,6-dichloroanilino)-
- Benzenamine, 2,6-dichloro-N-2-imidazolidinylidene-
- Clonidine
Registry Numbers
CAS Registry Number
- 4205-90-7
FDA UNII
- MN3L5RMN02
Other Registry Number
- 57066-25-8
Related Registry Number
- 4205-91-8 (mono-hydrochloride)
System Generated Number
- 0004205907
Structure Descriptors
InChI
InChI=1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14)InChIKey
GJSURZIOUXUGAL-UHFFFAOYSA-NSmiles
Clc1cccc(Cl)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
child | TDLo | oral | 60ug/kg (0.06mg/kg) | VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION PERIPHERAL NERVE AND SENSATION: SENSORY CHANGE INVOLVING PERIPHERAL NERVE | Critical Care Medicine. Vol. 18, Pg. 1124, 1990. |
child | TDLo | unreported | 5ug/kg (0.005mg/kg) | CARDIAC: PULSE RATE CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE CARDIAC: CARDIOMYOPATHY INCLUDING INFARCTION | Pediatrics. Vol. 96, Pg. 1176, 1995. |
dog | LD | skin | > 20mg/kg (20mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BLOOD: CHANGES IN LEUCOCYTE (WBC) COUNT SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE | Oyo Yakuri. Pharmacometrics. Vol. 48, Pg. 321, 1994. |
dog | LDLo | subcutaneous | 15mg/kg (15mg/kg) | LUNGS, THORAX, OR RESPIRATION: CYANOSIS LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Oyo Yakuri. Pharmacometrics. Vol. 45, Pg. 249, 1993. |
mammal (species unspecified) | LD50 | intraperitoneal | 102mg/kg (102mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 35, Pg. 693, 1985. | |
man | TDLo | oral | 2857ng/kg (0.002857mg/kg) | VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION | Archives of Internal Medicine. Vol. 143, Pg. 2195, 1983. |
man | TDLo | oral | 5ug/kg/9W-I (0.005mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) | European Journal of Clinical Pharmacology. Vol. 50, 463. |
man | TDLo | oral | 43ug/kg/10H-I (0.043mg/kg) | CARDIAC: PULSE RATE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ANTIPSYCHOTIC | Annals of Emergency Medicine. Vol. 17, Pg. 387, 1988. |
man | TDLo | oral | 583ug/kg/15W- (0.583mg/kg) | ENDOCRINE: HYPERGLYCEMIA KIDNEY, URETER, AND BLADDER: PROTEINURIS | American Journal of Medicine. Vol. 80, Pg. 545, 1986. |
mouse | LD50 | intravenous | 180mg/kg (180mg/kg) | U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#01892, | |
mouse | LD50 | oral | 108mg/kg (108mg/kg) | SKIN AND APPENDAGES (SKIN): HAIR: OTHER BEHAVIORAL: ATAXIA BEHAVIORAL: TREMOR | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 18, Pg. 366, 1987. |
mouse | LD50 | subcutaneous | 364mg/kg (364mg/kg) | SKIN AND APPENDAGES (SKIN): HAIR: OTHER BEHAVIORAL: ATAXIA BEHAVIORAL: TREMOR | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 18, Pg. 366, 1987. |
rat | LD50 | intraperitoneal | 88400ug/kg (88.4mg/kg) | BEHAVIORAL: TREMOR BEHAVIORAL: ATAXIA SENSE ORGANS AND SPECIAL SENSES: CHROMODACYRORREA: EYE | Kiso to Rinsho. Clinical Report. Vol. 26, Pg. 4835, 1992. |
rat | LD50 | oral | 67300ug/kg (67.3mg/kg) | United States Patent Document. Vol. #4389403, | |
rat | LD50 | skin | > 70mg/kg (70mg/kg) | SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE SENSE ORGANS AND SPECIAL SENSES: CHROMODACYRORREA: EYE SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION | Oyo Yakuri. Pharmacometrics. Vol. 45, Pg. 257, 1993. |
rat | LD50 | subcutaneous | 108mg/kg (108mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA SKIN AND APPENDAGES (SKIN): HAIR: OTHER | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 18, Pg. 366, 1987. |
women | TDLo | oral | 30ug/kg (0.03mg/kg) | VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION CARDIAC: PULSE RATE BEHAVIORAL: GENERAL ANESTHETIC | American Journal of Emergency Medicine. Vol. 14, Pg. 678, 1996. |
women | TDLo | oral | 225ug/kg (0.225mg/kg) | BEHAVIORAL: SLEEP CARDIAC: PULSE RATE VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION | British Medical Journal. Vol. 4, Pg. 23, 1975. |
women | TDLo | oral | 400ug/kg (0.4mg/kg) | Critical Care Medicine. Vol. 11, Pg. 959, 1983. | |
women | TDLo | oral | 400ug/kg (0.4mg/kg) | CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) | Critical Care Medicine. Vol. 11, Pg. 959, 1983. |
women | TDLo | unreported | 376ug/kg/4D-I (0.376mg/kg) | CARDIAC: CARDIOMYOPATHY INCLUDING INFARCTION CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE CARDIAC: PULSE RATE | Pediatrics. Vol. 96, Pg. 1176, 1995. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 130 | deg C | EXP | |
pKa Dissociation Constant | 8.05 | (none) | 25 | EXP |
log P (octanol-water) | 1.59 | (none) | EXP | |
Water Solubility | 1.36E+04 | mg/L | 25 | EST |
Vapor Pressure | 2.28E-05 | mm Hg | 25 | EST |
Henry's Law Constant | 1.51E-11 | atm-m3/mole | 25 | EST |
Atmospheric OH Rate Constant | 1.41E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.