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Substance Name: Tropifexor [USAN:INN]
RN: 1383816-29-2
UNII: NMZ08KM76Z
InChIKey: VYLOOGHLKSNNEK-PIIMJCKOSA-N

Note

  • Novel and highly potent agonist of farnesoid X receptor (FXR).

Classification Code

  • Treatment of Non-Alcoholic Stearohepatitis

Molecular Formula

  • C29-H25-F4-N3-O5-S

Molecular Weight

  • 603.5905
 
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Names and Synonyms

Results Name

  • Tropifexor [USAN:INN]

Name of Substance

  • Tropifexor
  • Tropifexor [USAN]

Synonyms

  • 2-((1R,5S)-3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)-1,2-oxazol-4-yl)methoxy)-8-azabicyclo(3.2.1)octan-8-yl)-4-fluoro-1,3-benzothiazole-6-carboxylic acid
  • LJN452
  • NVP-LJN452-NXA
  • Tropifexor
  • Tropifexor [INN]
  • UNII-NMZ08KM76Z
  • WHO 10443

Registry Numbers

CAS Registry Number

  • 1383816-29-2

FDA UNII

  • NMZ08KM76Z

System Generated Number

  • 1383816292

Structure Descriptors

InChI

InChI=1S/C29H25F4N3O5S/c30-21-9-15(27(37)38)10-23-25(21)34-28(42-23)36-16-7-8-17(36)12-18(11-16)39-13-20-24(35-41-26(20)14-5-6-14)19-3-1-2-4-22(19)40-29(31,32)33/h1-4,9-10,14,16-18H,5-8,11-13H2,(H,37,38)/t16-,17+,18+

InChIKey

VYLOOGHLKSNNEK-PIIMJCKOSA-N

Smiles

OC(=O)c1cc(F)c2nc(sc2c1)N3[C@@H]4CC[C@H]3C[C@H](C4)OCc5c(onc5c6ccccc6OC(F)(F)F)C7CC7