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Substance Name: Diethylcarbamazine citrate [USP:JAN]
RN: 1642-54-2
UNII: OS1Z389K8S
InChIKey: PGNKBEARDDELNB-UHFFFAOYSA-N

Note

  • An anthelmintic used primarily as the citrate in the treatment of filariasis, particularly infestations with Wucheria bancrofti or Loa loa.

Molecular Formulas

  • C10-H21-N3-O.C6-H8-O7
  • C16-H29-N3-O8

Molecular Weight

  • 391.418
 

Classification Codes

  • Anthelmintic
  • Drug / Therapeutic Agent
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Diethylcarbamazine citrate
  • Diethylcarbamazine citrate [USP:JAN]

Synonyms

  • 1-Diethylcarbamoyl-4-methylpiperazine dihydrogen citrate
  • 1-Methyl-4-diethylcarbamoylpiperazine citrate
  • 1-Piperazinecarboxamide, N,N-diethyl-4-methyl-, 2-hydroxy-1,2,3-propanetricarboxylate
  • 1-Piperazinecarboxamide, N,N-diethyl-4-methyl-, citrate
  • Banocide
  • Carbam Palatabs
  • Caritrol
  • Carricide citrate
  • D.E.C. Sol
  • DEC Chewable
  • Dek-Tabs
  • Dicarocide
  • Diethylcarbamazane citrate
  • Diethylcarbamazine acid citrate
  • Diethylcarbamazine citrate
  • Diethylcarbamazine dihydrogen citrate
  • Diethylcarbamazine hydrogen citrate
  • Diethylcarbamazini citras
  • Diro-Form
  • Dirocide
  • Ditrazin citrate
  • Ditrazine
  • Ditrazine citrate
  • Ditrazini citras
  • Ditrazinum
  • EINECS 216-696-6
  • Eosinopin
  • Ethodryl citrate
  • Filarabits
  • Filazine
  • Franocide
  • Franozan
  • Hetrazan
  • HSDB 6421
  • Longicid
  • Loxuran
  • N,N-Diethyl-4-methyl-1-piperazine carboxamide citrate
  • N,N-Diethyl-4-methyl-1-piperazinecarboxamide citrate (1:1)
  • N,N-Diethyl-4-methyl-1-piperazinecarboxamide dihydrogen citrate
  • N,N-Diethyl-4-methyl-1-piperazinecarboxamide dihydrogen citrate (1:1)
  • Nemacide
  • Notezine
  • NSC 80513
  • RP 3799
  • UNII-OS1Z389K8S

Systematic Names

  • 1-Piperazinecarboxamide, N,N-diethyl-4-methyl-, 2-hydroxy-1,2,3-propanetricarboxylate
  • 1-Piperazinecarboxamide, N,N-diethyl-4-methyl-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1)
  • 1-Piperazinecarboxamide, N,N-diethyl-4-methyl-, citrate (1:1)
  • Diethylcarbamazine dihydrogen citrate

Superlist Name

  • Diethylcarbamazine citrate

Registry Numbers

CAS Registry Number

  • 1642-54-2

FDA UNII

  • OS1Z389K8S

Related Registry Number

  • 90-89-1 (Parent)

System Generated Number

  • 0001642542

Molecular Formulas

Molecular Formulas

  • C10-H21-N3-O.C6-H8-O7
  • C16-H29-N3-O8

Molecular Formula Fragments

  • C10-H21-N3-O
  • C6-H8-O7
  • COMPONENT

Structure Descriptors

InChI

InChI=1S/C10H21N3O.C6H8O7/c1-4-12(5-2)10(14)13-8-6-11(3)7-9-13;7-3(8)1-6(13,5(11)12)2-4(9)10/h4-9H2,1-3H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)

InChIKey

PGNKBEARDDELNB-UHFFFAOYSA-N

Smiles

CCN(CC)C(=O)N1CCN(C)CC1.OC(=O)CC(O)(CC(=O)O)C(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 425mg/kg (425mg/kg)   Indian Journal of Chemistry, Section B: Organic Chemistry, Including Medicinal Chemistry. Vol. 26, Pg. 748, 1987.
mouse LD50 intravenous 180mg/kg (180mg/kg)   U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#00466,
mouse LD50 oral 660mg/kg (660mg/kg)   "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 41, 1969.
mouse LD50 subcutaneous 608mg/kg (608mg/kg)   Drugs in Japan Vol. 6, Pg. 306, 1982.
rat LC50 inhalation 309mg/m3/4H (309mg/m3)   "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 63, 1982.
rat LD50 oral 1400mg/kg (1400mg/kg)   Fortschritte der Arzneimittelforschung. Progress in Drug Research. Vol. 17, Pg. 108, 1973.
rat LD50 subcutaneous 1136mg/kg (1136mg/kg)   Drugs in Japan Vol. 6, Pg. 306, 1982.