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Substance Name: Phenacemide [USP:INN:BAN]
RN: 63-98-9
UNII: PAI7J52V09
InChIKey: XPFRXWCVYUEORT-UHFFFAOYSA-N

Note

  • Anti-epileptic drug.

Molecular Formula

  • C9-H10-N2-O2

Molecular Weight

  • 178.19
 

Classification Codes

  • Anticonvulsant
  • Drug / Therapeutic Agent
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Phenacemide
  • Phenacemide [USP:INN:BAN]

Synonyms

  • (Phenylacetyl)urea
  • 4-09-00-01636 (Beilstein Handbook Reference)
  • A-1348
  • Acetylureum
  • Benzeneacetamide, N-(aminocarbonyl)-
  • BRN 2048735
  • Carbamide phenylacetate
  • Carbanmide
  • Cetylureum
  • Comitiadone
  • Eferon
  • Efron
  • EINECS 200-570-2
  • Epheron
  • Epiclase
  • Felurea
  • Fenacemid
  • Fenacemida
  • Fenacemida [INN-Spanish]
  • Fenacemide
  • Fenacemide [DCIT]
  • Fenacetamide
  • Fenacetil-karbamide
  • Fenilep
  • Fenised
  • Fenostenyl
  • Fenural
  • Fenurea
  • Fenurone
  • Fenylacetylmocovina
  • Fenylacetylmocovina [Czech]
  • Fenytan
  • HSDB 3380
  • N-(Aminocarbonyl)benzeneacetamide
  • Neophedan
  • Neophenal
  • NSC 39458
  • Phacetur
  • Phenacalum
  • Phenacemide
  • Phenacemidum
  • Phenacemidum [INN-Latin]
  • Phenacereum
  • Phenacerum
  • Phenacetur
  • Phenacetylcarbamide
  • Phenacetylurea
  • Phenarone
  • Phenicarb
  • Phenuron
  • Phenurone
  • Phenutal
  • Phenylacetyluree
  • Phenylacetyluree [French]
  • Phenylethylacetylurea
  • Phenyrit
  • Phetylureum
  • Trioxanona
  • UNII-PAI7J52V09
  • Urea, (phenylacetyl)-

Systematic Names

  • Benzeneacetamide, N-(aminocarbonyl)-
  • Phenacemide
  • Urea, (phenylacetyl)-

Superlist Name

  • Phenacemide

Registry Numbers

CAS Registry Number

  • 63-98-9

FDA UNII

  • PAI7J52V09

System Generated Number

  • 0000063989

Structure Descriptors

InChI

InChI=1S/C9H10N2O2/c10-9(13)11-8(12)6-7-4-2-1-3-5-7/h1-5H,6H2,(H3,10,11,12,13)

InChIKey

XPFRXWCVYUEORT-UHFFFAOYSA-N

Smiles

NC(=O)NC(=O)Cc1ccccc1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo oral 2gm/kg (2000mg/kg)   "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. 188, 1973.
dog LDLo oral 3500mg/kg (3500mg/kg)   "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. 188, 1973.
guinea pig LD50 oral 882mg/kg (882mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 91, Pg. 437, 1952.
mouse LD50 intraperitoneal 1550mg/kg (1550mg/kg)   Research Progress in Organic-Biological and Medicinal Chemistry. Vol. 2, Pg. 309, 1970.
mouse LD50 oral 987mg/kg (987mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: COMA
Arzneimittel-Forschung. Drug Research. Vol. 18, Pg. 524, 1968.
rabbit LD50 intraperitoneal 2500mg/kg (2500mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 366, 1972.
rabbit LD50 oral 2500mg/kg (2500mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 366, 1972.
rat LD50 oral 1600mg/kg (1600mg/kg)   Acta Biologica et Medica Germanica. Vol. 2, Pg. 335, 1959.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 215 deg C   EXP
log P (octanol-water) 0.87 (none)   EXP
Water Solubility 1.02E+04 mg/L 25 EST
Vapor Pressure 8.94E-08 mm Hg 25 EST
Henry's Law Constant 8.71E-12 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 7.55E-12 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.