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Substance Name: Coumermycin [USAN]
RN: 4434-05-3
UNII: PCH9QZ1IIH
InChIKey: WTIJXIZOODAMJT-DHFGXMAYSA-N
Classification Codes
- Antibacterial
- Antineoplastic Agents
- Drug / Therapeutic Agent
- Enzyme Inhibitors
- Mutation Data
- Natural Product
- Topoisomerase II Inhibitors
Molecular Formula
- C55-H59-N5-O20
Molecular Weight
- 1110.0861
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Names and Synonyms
Name of Substance
- Coumamycin [INN]
- Coumermycin
- Coumermycin [USAN]
Synonyms
- 5-Methylpyrrole-2-carboxylic acid, diester with 3,3'-((3-methylpyrrole-2,4-diyl)bis(carbonylimino))bis(4-hydroxy-8-methyl-7-((tetrahydro-3,4-dihydroxy-5-methoxy-6,6-dimethylpyran-2-yl)oxy)coumarin)
- BRN 0470805
- Coumamycin
- Coumamycin (VAN)
- Coumamycine
- Coumamycine [INN-French]
- Coumamycinum
- Coumamycinum [INN-Latin]
- Coumermycin
- Coumermycin A1
- Cumamicina
- Cumamicina [INN-Spanish]
- Cumamycinum
- Notomycin
- Notomycin A1
- NSC 107412
- Sugordomycin D-1a
- Sugordomycin D-la
- UNII-PCH9QZ1IIH
Systematic Names
- 1H-Pyrrole-2-carboxylic acid, 5-methyl-, diester with N,N'-bis(7-((6-deoxy-5-C-methyl-4-O-methyl-alpha-L-lyxo-hexopyranosyl)oxy)-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl)-3-methyl-1H-pyrrole-2,4-dicarboxamide
- Pyrrole-2-carboxylic acid, 5-methyl-, diester with 3,3'-((3-methylpyrrole-2,4-diyl)bis(carbonylimino))bis(7-((5,5-di-C-methyl-4-O-methyl-alpha-L-lyxopyranosyl)oxy)-4-hydroxy-8-methylcoumarin)
Registry Numbers
CAS Registry Number
- 4434-05-3
FDA UNII
- PCH9QZ1IIH
Other Registry Numbers
- 11035-12-4
- 1372-92-5
- 22260-48-6
- 22850-02-8
- 23249-07-2
- 30418-37-2
- 30546-09-9
System Generated Number
- 0004434053
Structure Descriptors
InChI
InChI=1S/C55H59N5O20/c1-21-12-16-29(57-21)48(67)77-42-38(63)52(79-54(6,7)44(42)71-10)73-31-18-14-26-36(61)34(50(69)75-40(26)24(31)4)59-46(65)28-20-56-33(23(28)3)47(66)60-35-37(62)27-15-19-32(25(5)41(27)76-51(35)70)74-53-39(64)43(45(72-11)55(8,9)80-53)78-49(68)30-17-13-22(2)58-30/h12-20,38-39,42-45,52-53,56-58,61-64H,1-11H3,(H,59,65)(H,60,66)/t38-,39-,42+,43+,44-,45-,52-,53-/m1/s1InChIKey
WTIJXIZOODAMJT-DHFGXMAYSA-NSmiles
CO[C@@H]1[C@@H](OC(=O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intramuscular | 500mg/kg (500mg/kg) | "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978Vol. 1, Pg. 147, 1978. | |
mouse | LD50 | intraperitoneal | 159mg/kg (159mg/kg) | "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978Vol. 1, Pg. 147, 1978. | |
mouse | LD50 | intravenous | 25mg/kg (25mg/kg) | "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978Vol. 1, Pg. 147, 1978. | |
mouse | LD50 | oral | 2gm/kg (2000mg/kg) | "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978Vol. 1, Pg. 147, 1978. | |
mouse | LD50 | subcutaneous | 250mg/kg (250mg/kg) | Antimicrobial Agents and Chemotherapy Vol. -, Pg. 786, 1965. |