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Substance Name: Ascorbic acid [USP:INN:BAN:JAN]
RN: 50-81-7
UNII: PQ6CK8PD0R
InChIKey: CIWBSHSKHKDKBQ-JLAZNSOCSA-N

Note

  • A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.

Molecular Formula

  • C6-H8-O6

Molecular Weight

  • 176.1232
 

Classification Codes

  • Acidifier (Urinary)
  • Antioxidants
  • Antiviral (COVID-19)
  • Drug / Therapeutic Agent
  • Growth Substances
  • Human Data
  • Micronutrients
  • Mutation Data
  • Protective Agents
  • Reproductive Effect
  • Tumor Data
  • Vitamin (Antiscorbutic)
  • Vitamins

Names and Synonyms

Name of Substance

  • Ascorbic acid
  • Ascorbic acid [USP:INN:BAN:JAN]
  • L-Ascorbic acid
  • Vitamin C

MeSH Heading

  • Ascorbic acid

Synonyms

  • 3-Keto-L-gulofuranolactone
  • 3-Oxo-L-gulofuranolactone
  • 3-Oxo-L-gulofuranolactone (enol form)
  • Acide ascorbique
  • Acide ascorbique [INN-French]
  • Acido ascorbico
  • Acido ascorbico [INN-Spanish]
  • Acidum ascorbicum
  • Acidum ascorbicum [INN-Latin]
  • Acidum ascorbinicum
  • Adenex
  • Allercorb
  • Antiscorbic vitamin
  • Antiscorbutic vitamin
  • Arco-cee
  • Ascoltin
  • Ascor
  • Ascor-B.I.D.
  • Ascorb
  • Ascorbajen
  • Ascorbate
  • Ascorbic acid
  • Ascorbicap
  • Ascorbutina
  • Ascorin
  • Ascorteal
  • Ascorvit
  • C-Level
  • C-Long
  • C-Quin
  • C-Span
  • C-Vimin
  • Cantan
  • Cantaxin
  • Caswell No. 061B
  • Catavin C
  • CCRIS 57
  • ce lent
  • Ce-Mi-Lin
  • CE-VI-Sol
  • Cebicure
  • Cebid
  • Cebion
  • Cebione
  • Cecon
  • Cee-caps TD
  • Cee-vite
  • Cegiolan
  • Ceglion
  • Celaskon
  • Celin
  • Cemagyl
  • Cemill
  • Cenetone
  • Cenolate
  • Cereon
  • Cergona
  • Cescorbat
  • Cetamid
  • Cetane
  • Cetane-Caps TC
  • Cetane-caps TD
  • Cetemican
  • Cevalin
  • Cevatine
  • Cevex
  • Cevi-bid
  • Cevimin
  • Cevital
  • Cevitamic acid
  • Cevitamin
  • Cevitan
  • Cevitex
  • Cewin
  • Ciamin
  • Cipca
  • Citriscorb
  • Colascor
  • Concemin
  • Davitamon C
  • Dora-C-500
  • Duoscorb
  • EINECS 200-066-2
  • FEMA No. 2109
  • Hex-2-enonic acid gamma-lactone, L-threo-
  • Hicee
  • HSDB 818
  • Hybrin
  • IDO-C
  • Kyselina askorbova
  • Kyselina askorbova [Czech]
  • L(+)-Ascorbic acid
  • L-3-Ketothreohexuronic acid lactone
  • L-Ascorbate
  • L-Lyxoascorbic acid
  • L-threo-Hex-2-enonic acid, gamma-lactone
  • L-Xyloascorbic acid
  • Laroscorbine
  • Lemascorb
  • Liqui-Cee
  • Meri-C
  • Natrascorb
  • Natrascorb injectable
  • NCI-C54808
  • NSC 218455
  • NSC 33832
  • Planavit C
  • Proscorbin
  • Redoxon
  • Ribena
  • Roscorbic
  • Scorbacid
  • Scorbu-C
  • Secorbate
  • Testascorbic
  • UNII-PQ6CK8PD0R
  • Vicelat
  • Vicomin C
  • Viforcit
  • Viscorin
  • Vitace
  • Vitacee
  • Vitacimin
  • Vitacin
  • Vitamin C
  • Vitamisin
  • Vitascorbol
  • Xitix

Systematic Names

  • Ascorbic acid
  • L-Ascorbic acid
  • Vitamin C

Superlist Names

  • Ascorbic acid
  • Ferrous ascorbate
  • L-Ascorbic acid

Mixture Names

  • Chromagen
  • Cortalex
  • Ferancee
  • Mediatric
  • Stuartinic
  • Tolfrinic

Registry Numbers

CAS Registry Number

  • 50-81-7

FDA UNII

  • PQ6CK8PD0R

Other Registry Numbers

  • 1018124-03-2
  • 1129294-89-8
  • 129940-97-2
  • 1428525-25-0
  • 14536-17-5
  • 154170-90-8
  • 1703051-92-6
  • 259133-78-3
  • 30208-61-8
  • 50976-75-5
  • 56172-55-5
  • 56533-05-2
  • 57304-74-2
  • 57606-40-3
  • 623158-95-2
  • 882690-91-7
  • 884381-69-5
  • 885512-24-3
  • 88845-26-5
  • 896436-13-8
  • 89924-69-6

Related Registry Number

  • 134-03-2 (monosodium salt)

System Generated Number

  • 0000050817

Structure Descriptors

InChI

InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/t2-,5+/m0/s1

InChIKey

CIWBSHSKHKDKBQ-JLAZNSOCSA-N

Smiles

OC[C@H](O)[C@H]1OC(=O)C(=C1O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo intravenous 2300mg/kg/2D (2300mg/kg) BLOOD: OXIDANT RELATED (GPD DEFICIENT) ANEMIA Annals of Internal Medicine. Vol. 82, Pg. 810, 1975.
mouse LD50 intraperitoneal 643mg/kg (643mg/kg)   Progress in Mutation Research. Vol. 1, Pg. 682, 1981.
mouse LD50 intravenous 518mg/kg (518mg/kg)   Research Progress in Organic-Biological and Medicinal Chemistry. Vol. 2, Pg. 269, 1970.
mouse LD50 oral 3367mg/kg (3367mg/kg)   National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986,
rat LD50 intravenous > 4gm/kg (4000mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)		 Oyo Yakuri. Pharmacometrics. Vol. 12, Pg. 131, 1976.
rat LD50 oral 11900mg/kg (11900mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"		 Oyo Yakuri. Pharmacometrics. Vol. 12, Pg. 131, 1976.
rat LD50 subcutaneous > 10gm/kg (10000mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 12, Pg. 131, 1976.
women LDLo intravenous 900mg/kg (900mg/kg) KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" Archives of Internal Medicine. Vol. 145, Pg. 950, 1985.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 191 dec deg C   EXP
pKa Dissociation Constant 4.7 (none) 10 EXP
log P (octanol-water) -1.85E+00 (none)   EXP
Water Solubility 4.00E+05 mg/L 40 EXP
Vapor Pressure 2.49E-10 mm Hg 25 EST
Henry's Law Constant 4.07E-08 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 5.58E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.