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Substance Name: Diazepam [USAN:USP:INN:BAN:JAN]
RN: 439-14-5
UNII: Q3JTX2Q7TU
InChIKey: AAOVKJBEBIDNHE-UHFFFAOYSA-N
Note
- A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
Molecular Formula
- C16-H13-Cl-N2-O
Molecular Weight
- 284.7447
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
Classification Codes
- Adjuvants, Anesthesia
- Anesthetics
- Anesthetics, General
- Anesthetics, Intravenous
- Anti-Anxiety Agents
- Anticonvulsants
- Antiemetics
- Autonomic Agents
- Central Nervous System Agents
- Central Nervous System Depressants
- Drug / Therapeutic Agent
- GABA Agents
- GABA Modulators
- Gastrointestinal Agents
- Human Data
- Hypnotics and Sedatives
- Muscle Relaxants, Central
- Mutation Data
- Neuromuscular Agents
- Neurotransmitter Agents
- Peripheral Nervous System Agents
- Psychotropic Drugs
- Reproductive Effect
- Sedative-Hypnotic
- Tranquilizing Agents
- Tumor Data
Superlist Classification Codes
- DEA Schedule IV
- Overall Carcinogenic Evaluation: Group 3
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Regulatory Agencies (Superlist Locators)
Other Resources (Internet Locators)
Search for this InChIKey on the Web
Names and Synonyms
Name of Substance
- Diazepam
- Diazepam [USAN:USP:INN:BAN:JAN]
MeSH Heading
- Diazepam
Synonyms
- 1-Methyl-5-phenyl-7-chloro-1,3-dihydro-2H-1,4-benzodiazepin-2-one
- 2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-1-methyl-5-phenyl-
- 5-24-04-00300 (Beilstein Handbook Reference)
- 7-Chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one
- 7-Chloro-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepine
- 7-Chloro-1-methyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one
- 7-Chloro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one
- 7-Chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2(1H)-one
- Alboral
- Aliseum
- Amiprol
- An-Ding
- Ansilive
- Ansiolin
- Ansiolisina
- Antenex
- Anxicalm
- Anxionil
- Apaurin
- Apo-diazepam
- Apozepam
- Armonil
- Arzepam
- Assival
- Atensine
- Atilen
- Azedipamin
- Baogin
- Bensedin
- Benzopin
- Best [Pharaceutical]
- Betapam
- Bialzepam
- Britazepam
- BRN 0754371
- Calmaven
- Calmocitene
- Calmociteno
- Calmod
- Calmpose
- Caudel
- CB 4261
- CCRIS 6009
- Centrazepam
- Cercine
- Ceregulart
- Chuansuan
- Condition
- D-Pam
- Desconet
- Desloneg
- Diacepan
- Diaceplex
- Dialag
- Dialar
- Diapam
- Diapax
- Diapine
- Diaquel
- Diastat
- Diastat Acudial
- Diatran
- Diazem
- Diazemuls
- Diazepam
- Diazepam Dak
- Diazepam Desitin
- Diazepam Elmu
- Diazepam Fabra
- Diazepam intensol
- Diazepam Nordic
- Diazepam Rectubes
- Diazepam Stada
- Diazepam-Eurogenerics
- Diazepam-Lipuro
- Diazepam-ratiopharm
- Diazepamu
- Diazepamu [Polish]
- Diazepamum
- Diazepamum [INN-Latin]
- Diazepan
- Diazepan leo
- Diazepin
- Diazetard
- Dienpax
- Dipaz
- Dipezona
- Disopam
- Dizac
- Domalium
- Doval
- Drenian
- Ducene
- Duksen
- Dupin
- Duxen
- DZP
- e-Pam
- EINECS 207-122-5
- Elcion CR
- Eridan
- Euphorin P
- Eurosan
- Evacalm
- Faustal
- Faustan
- Freudal
- Frustan
- Gewacalm
- Gihitan
- Gradual
- Gubex
- Horizon
- HSDB 3057
- Iazepam
- Jinpanfan
- Kabivitrum
- Kiatrium
- Kratium
- Kratium 2
- LA III
- LA-111
- Lamra
- Lembrol
- Levium
- Liberetas
- Lizan
- Lovium
- Mandro
- Mandro-Zep
- Medipam
- Mentalium
- Metamidol
- Methyl diazepinone
- Methyldiazepinone
- Methyldiazepinone (pharmaceutical)
- Metil Gobanal
- Morosan
- Nellium
- Nerozen
- Nervium
- Neurolytril
- Nivalen
- Nixtensyn
- Noan
- Notense
- Novazam
- Novodipam
- NSC 169897
- NSC-77518
- Ortopsique
- Paceum
- Paralium
- Paranten
- Parzam
- Pax
- Paxate
- Paxel
- Paxum
- Placidox 10
- Placidox 2
- Placidox 5
- Plidan
- Plumiaz
- Pomin
- Propam
- Prozepam
- Psychopax
- Q-Pam
- Quetinil
- Quiatril
- Quievita
- Radizepam
- Relaminal
- Relanium
- Relax
- Reliver
- Renborin
- Ro 5-2807
- Ruhsitus
- Saromet
- Sedipam
- Seduksen
- Seduxen
- Serenack
- Serenamin
- Serenzin
- Setonil
- Sibazon
- Sico Relax
- Simasedan
- Sipam
- Solis
- Sonacon
- Stesolid
- Stesolin
- Tensopam
- Tranimul
- Trankinon
- Tranqdyn
- Tranquirit
- Trazepam
- Umbrium
- UNII-Q3JTX2Q7TU
- Unisedil
- Usempax AP
- Valaxona
- Valeo
- Valiquid
- Valitran
- Valium
- Valrelease
- Valuzepam
- Vanconin
- Vatran
- Vazen
- Velium
- Vival
- Vivol
- Winii
- WY-3467
- Zepaxid
- Zipan
Systematic Names
- 2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-1-methyl-5-phenyl-
- Diazepam
Superlist Names
- DEA No. 2765
- Diazepam
Registry Numbers
CAS Registry Number
- 439-14-5
FDA UNII
- Q3JTX2Q7TU
Other Registry Numbers
- 11100-37-1
- 53320-84-6
System Generated Number
- 0000439145
Structure Descriptors
InChI
InChI=1S/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3InChIKey
AAOVKJBEBIDNHE-UHFFFAOYSA-NSmiles
CN1C(=O)Toxicity
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LD50 | parenteral | > 800mg/kg (800mg/kg) | Drugs in Japan Vol. -, Pg. 500, 1995. | |
| infant | TDLo | intravenous | 150ug/kg (0.15mg/kg) | SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" | British Medical Journal. Vol. 2, Pg. 298, 1977. |
| mammal (species unspecified) | LD50 | oral | 500mg/kg (500mg/kg) | Doklady Akademii Nauk SSSR. Proceedings of the Academy of Sciences of the USSR. For English translation, see DBIOAM and DKBSAS. Vol. 320, Pg. 242, 1991. | |
| mammal (species unspecified) | LD50 | unreported | 110mg/kg (110mg/kg) | Pharmaceutical Chemistry Journal Vol. 25, Pg. 193, 1991. | |
| man | TDLo | intravenous | 71ug/kg/1M-C (0.071mg/kg) | VASCULAR: OTHER CHANGES | Drug Intelligence and Clinical Pharmacy. Vol. 17, Pg. 125, 1983. |
| man | TDLo | intravenous | 143ug/kg (0.143mg/kg) | LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | JAMA, Journal of the American Medical Association. Vol. 238, Pg. 1052, 1977. |
| man | TDLo | oral | 143ug/kg (0.143mg/kg) | SENSE ORGANS AND SPECIAL SENSES: DIPLOPIA: EYE SENSE ORGANS AND SPECIAL SENSES: VISUAL FIELD CHANGES: EYE | British Journal of Clinical Pharmacology. Vol. 1, Pg. 335, 1974. |
| mouse | LD50 | intramuscular | 65mg/kg (65mg/kg) | European Journal of Pharmacology. Vol. 13, Pg. 150, 1971. | |
| mouse | LD50 | intraperitoneal | 37mg/kg (37mg/kg) | Strahlentherapie. Vol. 127, Pg. 245, 1965. | |
| mouse | LD50 | intravenous | 25mg/kg (25mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 2180, 1981. | |
| mouse | LD50 | oral | 48mg/kg (48mg/kg) | Pharmaceutical Chemistry Journal Vol. 17, Pg. 30, 1983. | |
| mouse | LD50 | parenteral | 80mg/kg (80mg/kg) | United States Patent Document. Vol. #4371536, | |
| mouse | LD50 | rectal | 500mg/kg (500mg/kg) | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 34, Pg. 2226, 1992. | |
| mouse | LD50 | skin | 800mg/kg (800mg/kg) | Anesteziologiya i Reanimatologiya. Vol. (4), Pg. 57, 1980. | |
| mouse | LD50 | subcutaneous | 800mg/kg (800mg/kg) | United States Patent Document. Vol. #3966793, | |
| mouse | LD50 | unreported | 140mg/kg (140mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) | Pharmaceutical Chemistry Journal Vol. 18, Pg. 266, 1984. |
| rabbit | LD50 | intravenous | 9mg/kg (9mg/kg) | BEHAVIORAL: REGIDITY BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE | International Journal of Neuropharmacology. Vol. 5, Pg. 305, 1966. |
| rabbit | LD50 | oral | 328mg/kg (328mg/kg) | Current Therapeutic Research, Clinical & Experimental. Vol. 7, Pg. 590, 1965. | |
| rat | LD50 | intraperitoneal | 46500ug/kg (46.5mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 682, 1992. | |
| rat | LD50 | intravenous | 32mg/kg (32mg/kg) | Current Therapeutic Research, Clinical & Experimental. Vol. 7, Pg. 590, 1965. | |
| rat | LD50 | oral | 249mg/kg (249mg/kg) | Drugs in Japan Vol. -, Pg. 500, 1995. | |
| rat | LD50 | parenteral | 131mg/kg (131mg/kg) | Drugs in Japan Vol. -, Pg. 500, 1995. | |
| rat | LD50 | rectal | 600mg/kg (600mg/kg) | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 34, Pg. 2226, 1992. | |
| rat | LD50 | subcutaneous | 6350ug/kg (6.35mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 682, 1992. | |
| women | TDLo | intramuscular | 181ug/kg (0.181mg/kg) | BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) BEHAVIORAL: GENERAL ANESTHETIC CARDIAC: CHANGE IN RATE | British Medical Journal. Vol. 1, Pg. 144, 1977. |
| women | TDLo | oral | 5mg/kg (5mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | British Journal of Obstetrics and Gynaecology. Vol. 100, Pg. 185, 1993. |
Physical Properties
| Physical Property | Value | Units | Temp (deg C) | Source |
|---|---|---|---|---|
| Melting Point | 132 | deg C | EXP | |
| pKa Dissociation Constant | 3.4 | (none) | EXP | |
| log P (octanol-water) | 2.82 | (none) | EXP | |
| Water Solubility | 50 | mg/L | 25 | EXP |
| Vapor Pressure | 2.78E-08 | mm Hg | 25 | EST |
| Henry's Law Constant | 3.64E-09 | atm-m3/mole | 25 | EST |
| Atmospheric OH Rate Constant | 9.90E-12 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.