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Substance Name: Budesonide [USAN:INN:BAN:JAN]
RN: 51333-22-3
UNII: Q3OKS62Q6X
InChIKey: VOVIALXJUBGFJZ-KWVAZRHASA-N

Note

  • A glucocorticoid used in the management of ASTHMA, the treatment of various skin disorders, and allergic RHINITIS.

Molecular Formula

  • C25-H34-O6

Molecular Weight

  • 430.5376
 

Classification Codes

  • Adrenal Cortex Hormones
  • Anti-Asthmatic Agents
  • Anti-Inflammatory
  • Anti-Inflammatory Agents
  • Autonomic Agents
  • Bronchodilator Agents
  • Drug / Therapeutic Agent
  • Glucocorticoids
  • Hormone
  • Hormones
  • Hormones, Hormone Substitutes, and Hormone Antagonists
  • Human Data
  • Peripheral Nervous System Agents
  • Reproductive Effect
  • Respiratory System Agents

Names and Synonyms

Name of Substance

  • Budesonide
  • Budesonide [USAN:INN:BAN:JAN]

MeSH Heading

  • Budesonide

Synonyms

  • (11-beta,16-alpha)-16,17-(Butylidenebis(oxy))-11,21-dihydroxypregna-1,4-diene-3,20-dione
  • (RS)-11beta,16alpha,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with butyraldehyde
  • 16-alpha,17-alpha-Butylidenedioxy-11-beta,21-dihydroxy-1,4-pregnadiene-3,20-dione
  • Bidien
  • Budecort Inhaler
  • Budeson
  • Budesonide
  • Budesonido
  • Budesonido [INN-Spanish]
  • Budesonidum
  • Budesonidum [INN-Latin]
  • CCRIS 5230
  • Cortivent
  • EINECS 257-139-7
  • Entocort
  • Entocort EC
  • Fvolir
  • HSDB 8279
  • Micronyl
  • Preferid
  • Pulmicort
  • Pulmicort Flexhaler
  • Pulmicort Respules
  • Respules
  • Rhinocort
  • Rhinocort Allergy
  • Rhinocort alpha
  • Rhinocort aqua
  • S 1320
  • Spirocort
  • Uceris
  • UNII-Q3OKS62Q6X

Systematic Names

  • Budesonide
  • Pregna-1,4-diene-3,20-dione, 16,17-(butylidenebis(oxy))-11,21-dihydroxy-, (11-beta,16-alpha)-
  • Pregna-1,4-diene-3,20-dione, 16,17-butylidenebis(oxy)-11,21-dihydroxy-, (11beta,16alpha(R))-, and 16alpha,17-((S)-Butylidenebis(oxy))-11beta,21-dihydroxypregna-1,4-diene-3,20-dione
  • Pregna-1,4-diene-3,20-dione,16,17-(butylidenebis(oxy))-11,21-dihydroxy-, (11beta,16alpha)-

Registry Numbers

CAS Registry Number

  • 51333-22-3

FDA UNII

  • Q3OKS62Q6X

System Generated Number

  • 0051333223

Structure Descriptors

InChI

1S/C25H34O6/c1-4-5-21-30-20-11-17-16-7-6-14-10-15(27)8-9-23(14,2)22(16)18(28)12-24(17,3)25(20,31-21)19(29)13-26/h8-10,16-18,20-22,26,28H,4-7,11-13H2,1-3H3/t16-,17-,18-,20+,21?,22+,23-,24-,25+/m0/s1

InChIKey

VOVIALXJUBGFJZ-KWVAZRHASA-N

Smiles

CCCC1O[C@@H]2C[C@H]3[C@@H]4CCC5=CC(=O)C=C[C@@]5([C@H]4[C@H](C[C@@]3([C@@]2(O1)C(=O)CO)C)O)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 subcutaneous 173mg/kg (173mg/kg) BLOOD: CHANGES IN SPLEEN

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH
Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 4377, 1985.
man TCLo inhalation 34ug/kg (0.034mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, ALLERGIC: AFTER SYSTEMIC EXPOSURE" Australian and New Zealand Journal of Medicine. Vol. 22, Pg. 511, 1992.
mouse LD50 intraperitoneal 179mg/kg (179mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 4377, 1985.
mouse LD50 intravenous 124mg/kg (124mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 4377, 1985.
mouse LD50 oral 4750mg/kg (4750mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 4377, 1985.
mouse LD50 subcutaneous 53600ug/kg (53.6mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 4377, 1985.
rat LD50 intraperitoneal 138mg/kg (138mg/kg) BLOOD: CHANGES IN SPLEEN

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 4377, 1985.
rat LD50 intravenous 98900ug/kg (98.9mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 4377, 1985.
rat LD50 oral > 3200mg/kg (3200mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 4377, 1985.
rat LD50 subcutaneous 58400ug/kg (58.4mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BLOOD: CHANGES IN SPLEEN
Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 4377, 1985.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 226 dec deg C   EXP
log P (octanol-water) 2.180 (none)   EST
Atmospheric OH Rate Constant 1.28E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.