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Substance Name: Vinorelbine [INN:BAN]
RN: 71486-22-1
UNII: Q6C979R91Y
InChIKey: GBABOYUKABKIAF-IELIFDKJSA-N
Note
- A vinca alkaloid related to VINBLASTINE that is used as a first-line treatment for NON-SMALL CELL LUNG CANCER, or for advanced or metastatic BREAST CANCER refractory to treatment with ANTHRACYCLINES.
Molecular Formula
- C45-H54-N4-O8
Molecular Weight
- 778.9416
Classification Codes
- Antimitotic Agents
- Antineoplastic Agents
- Antineoplastic Agents, Phytogenic
- Drug / Therapeutic Agent
- Tubulin Modulators
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Names and Synonyms
Name of Substance
- Vinorelbine
- Vinorelbine [INN:BAN]
MeSH Heading
- Vinorelbine
Synonyms
- Exelbine
- HSDB 7665
- KW 2307 base
- Navelbine base
- Nor-5'-anhydrovinblastine
- NSC 760087
- UNII-Q6C979R91Y
- Vinorelbina
- Vinorelbina [Spanish]
- Vinorelbine
- Vinorelbinum
- Vinorelbinum [Latin]
Systematic Names
- Aspidospermidine-3-carboxylic acid, 4-(acetyloxy)-6,7-didehydro-15-((2R,6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino(4,3-b)indol-8-yl)-3-hydroxy-16-methoxy-1-methyl-, methyl ester, (2beta,3beta,4beta,5alpha,12beta,19alpha)-
- Aspidospermidine-3-carboxylic acid, 4-(acetyloxy)-6,7-didehydro-15-((2R,6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino(4,3-b)indol-8-yl)-3-hydroxy-16-methoxy-1-methyl-, methyl ester, (2beta,3beta,4beta,5alpha,12R,19alpha)-
- C'-Norvincaleukoblastine, 3',4'-didehydro-4'-deoxy-
Registry Numbers
CAS Registry Number
- 71486-22-1
FDA UNII
- Q6C979R91Y
System Generated Number
- 0071486221
Structure Descriptors
InChI
InChI=1S/C45H54N4O8/c1-8-27-19-28-22-44(40(51)55-6,36-30(25-48(23-27)24-28)29-13-10-11-14-33(29)46-36)32-20-31-34(21-35(32)54-5)47(4)38-43(31)16-18-49-17-12-15-42(9-2,37(43)49)39(57-26(3)50)45(38,53)41(52)56-7/h10-15,19-21,28,37-39,46,53H,8-9,16-18,22-25H2,1-7H3/t28-,37-,38+,39+,42+,43+,44-,45-/m0/s1InChIKey
GBABOYUKABKIAF-IELIFDKJSA-NSmiles
CCC1=C[C@@H]2CN(C1)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 26mg/kg (26mg/kg) | Gan to Kagaku Ryoho. Cancer and Chemotherapy. Vol. 10, Pg. 1050, 1983. |