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Substance Name: Afamelanotide [USAN:INN]
RN: 75921-69-6
UNII: QW68W3J66U
InChIKey: UAHFGYDRQSXQEB-LEBBXHLNSA-N

Note

  • Observations suggest that afamelanotide has beneficial effects in patients with erythropoietic protoporphyria, induces epidermal melanin formation.

Molecular Formula

  • C78-H111-N21-O19

Molecular Weight

  • 1646.8629
 

Classification Codes

  • Affinity Labels
  • Anticarcinogenic Agents
  • Antineoplastic Agents
  • Dermatologic Agents
  • Indicators and Reagents
  • Prevention of Phototoxicity in Adults with Erythropoietic Protoporphyria (EPP)
  • Protective Agents
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Names and Synonyms

Name of Substance

  • Afamelanotide [USAN:INN]
  • Msh, 4-nle-7-phe-alpha-

Synonyms

  • (Nle(4)-dphe(7))alpha-melanocyte-stimulating hormone
  • (Nle4,D-Phe7)-alpha-MSH
  • (Nle4-D-Phe7)-alpha-Melanocyte-stimulating hormone
  • 4-Nle-7-phe-alpha-msh
  • 4-Norleucine-7-D-phenylalanine-alpha-melanocyte-stimulating hormone
  • 4-Norleucyl-7-phenylalanine-alpha-msh
  • Afamelanotide
  • alpha-Msh, nle(4)-phe(7)-
  • alpha-Msh, norleucyl(4)-D-phenylalanyl(7)-
  • CUV 1647
  • CUV1647
  • MBJ 05
  • Melanotan I
  • Melanotan-1
  • Msh, 4-norleucyl-7-phenylalanine-alpha-
  • MT-1 (Nlefmsh)
  • Ndp-msh
  • UNII-QW68W3J66U

Systematic Name

  • alpha-Melanotropin, 4-L-norleucine-7-D-phenylalanine-

Registry Numbers

CAS Registry Number

  • 75921-69-6

FDA UNII

  • QW68W3J66U

Other Registry Numbers

  • 103088-28-4
  • 162112-36-9
  • 272781-22-3

System Generated Number

  • 0075921696

Structure Descriptors

InChI

1S/C78H111N21O19/c1-5-6-19-52(91-75(116)61(41-101)97-72(113)57(34-46-24-26-49(103)27-25-46)94-74(115)60(40-100)88-44(4)102)68(109)92-54(28-29-64(105)106)70(111)96-59(36-48-38-83-42-87-48)73(114)93-56(33-45-16-8-7-9-17-45)71(112)90-53(22-14-31-84-78(81)82)69(110)95-58(35-47-37-85-51-20-11-10-18-50(47)51)67(108)86-39-63(104)89-55(21-12-13-30-79)77(118)99-32-15-23-62(99)76(117)98-65(43(2)3)66(80)107/h7-11,16-18,20,24-27,37-38,42-43,52-62,65,85,100-101,103H,5-6,12-15,19,21-23,28-36,39-41,79H2,1-4H3,(H2,80,107)(H,83,87)(H,86,108)(H,88,102)(H,89,104)(H,90,112)(H,91,116)(H,92,109)(H,93,114)(H,94,115)(H,95,110)(H,96,111)(H,97,113)(H,98,117)(H,105,106)(H4,81,82,84)/t52-,53-,54-,55-,56+,57-,58-,59-,60-,61-,62-,65-/m0/s1

InChIKey

UAHFGYDRQSXQEB-LEBBXHLNSA-N

Smiles

CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@H](Cc3ccccc3)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc4c[nH]c5ccccc45)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N6CCC[C@H]6C(=O)N[C@@H](C(C)C)C(=O)N