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Substance Name: Niaprazine [INN:DCF]
RN: 27367-90-4
UNII: R2H3YN6E3L
InChIKey: RSKQGBFMNPDPLR-UHFFFAOYSA-N

Note

  • Selective brain catecholamine depletor.

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C20-H25-F-N4-O

Molecular Weight

  • 356.443
 
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Names and Synonyms

Name of Substance

  • Niaprazine
  • Niaprazine [INN:DCF]

Synonyms

  • 1709 CERM
  • 5-23-01-00362 (Beilstein Handbook Reference)
  • BRN 0844157
  • EINECS 248-431-5
  • N-(3-(4-(4-Fluorophenyl)-1-piperazinyl)-1-methylpropyl)-3-pyridinecarboxamide
  • N-(3-(4-(p-Fluorophenyl)-1-piperazinyl)-1-methylpropyl)nicotinamide
  • Niaprazina
  • Niaprazina [INN-Spanish]
  • Niaprazine
  • Niaprazinum
  • Niaprazinum [INN-Latin]
  • Nopron
  • UNII-R2H3YN6E3L

Systematic Names

  • 3-Pyridinecarboxamide, N-(3-(4-(4-fluorophenyl)-1-piperazinyl)-1-methylpropyl)-
  • N-(3-(4-(4-Fluorophenyl)-1-piperazinyl)-1-methylpropyl)-3-pyridinecarboxamide
  • N-(3-(4-(p-Fluorophenyl)-1-piperazinyl)-1-methylpropyl)nicotinamide
  • Niaprazine
  • Nicotinamide, N-(3-(4-(p-fluorophenyl)-1-piperazinyl)-1-methylpropyl)-

Registry Numbers

CAS Registry Number

  • 27367-90-4

FDA UNII

  • R2H3YN6E3L

Related Registry Number

  • 34426-53-4 (tri-hydrochloride)

System Generated Number

  • 0027367904

Structure Descriptors

InChI

InChI=1S/C20H25FN4O/c1-16(23-20(26)17-3-2-9-22-15-17)8-10-24-11-13-25(14-12-24)19-6-4-18(21)5-7-19/h2-7,9,15-16H,8,10-14H2,1H3,(H,23,26)

InChIKey

RSKQGBFMNPDPLR-UHFFFAOYSA-N

Smiles

CC(CCN1CCN(CC1)c2ccc(F)cc2)NC(=O)c3cccnc3

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 145mg/kg (145mg/kg)   German Offenlegungsschrift Patent Document. Vol. #1957371,
mouse LD50 oral 890mg/kg (890mg/kg)   German Offenlegungsschrift Patent Document. Vol. #1957371,