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Substance Name: Flunarizine [INN:BAN]
RN: 52468-60-7
UNII: R7PLA2DM0J
InChIKey: SMANXXCATUTDDT-QPJJXVBHSA-N
Note
- Flunarizine is a selective calcium entry blocker with calmodulin binding properties and histamine H1 blocking activity. It is effective in the prophylaxis of migraine, occlusive peripheral vascular disease, vertigo of central and peripheral origin, and as an adjuvant in the therapy of epilepsy.
Molecular Formula
- C26-H26-F2-N2
Molecular Weight
- 404.5014
- All
- Classifications
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- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Anticonvulsants
- Calcium Channel Blockers
- Calcium-Regulating Hormones and Agents
- Cardiovascular Agents
- Central Nervous System Agents
- Drug / Therapeutic Agent
- Histamine Agents
- Histamine Antagonists
- Histamine H1 Antagonists
- Human Data
- Membrane Transport Modulators
- Neurotransmitter Agents
- Vasodilator Agents
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Names and Synonyms
Name of Substance
- Flunarizine
- Flunarizine [INN:BAN]
MeSH Heading
- Flunarizine
Synonyms
- (E)-1-(Bis(4-fluorophenyl)methyl)-4-(3-phenyl-2-propenyl)piperazine
- EINECS 257-937-5
- Flunarizina
- Flunarizina [INN-Spanish]
- Flunarizine
- Flunarizinum
- Flunarizinum [INN-Latin]
- Narzine
- Sibelium
- UNII-R7PLA2DM0J
Systematic Names
- Flunarizine
- Piperazine, 1-(bis(4-fluorophenyl)methyl)-4-(3-phenyl-2-propenyl)-, (E)-
Registry Numbers
CAS Registry Number
- 52468-60-7
FDA UNII
- R7PLA2DM0J
Related Registry Number
- 30484-77-6 (di-hydrochloride)
System Generated Number
- 0052468607
Structure Descriptors
InChI
InChI=1S/C26H26F2N2/c27-24-12-8-22(9-13-24)26(23-10-14-25(28)15-11-23)30-19-17-29(18-20-30)16-4-7-21-5-2-1-3-6-21/h1-15,26H,16-20H2/b7-4+InChIKey
SMANXXCATUTDDT-QPJJXVBHSA-NSmiles
Fc1ccc(cc1)Toxicity
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| man | TDLo | oral | 4286ug/kg/30D (4.286mg/kg) | BEHAVIORAL: TREMOR | Neurology. Vol. 37, Pg. 881, 1987. |
| mouse | LD50 | oral | 960mg/kg (960mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 37, Pg. 1103, 1987. | |
| women | TDLo | oral | 18mg/kg/90D-I (18mg/kg) | BEHAVIORAL: TREMOR | Neurology. Vol. 37, Pg. 881, 1987. |
| women | TDLo | oral | 73mg/kg/1Y-I (73mg/kg) | BEHAVIORAL: TREMOR BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Italian Journal of Neurological Sciences. Vol. 10, Pg. 89, 1989. |
Physical Properties
| Physical Property | Value | Units | Temp (deg C) | Source |
|---|---|---|---|---|
| log P (octanol-water) | 5.78 | (none) | EXP | |
| Water Solubility | 0.339 | mg/L | 25 | EST |
| Vapor Pressure | 1.68E-09 | mm Hg | 25 | EST |
| Henry's Law Constant | 5.53E-12 | atm-m3/mole | 25 | EST |
| Atmospheric OH Rate Constant | 2.66E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.