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Substance Name: Fenoprofen [USAN:INN:BAN]
RN: 29679-58-1
UNII: RA33EAC7KY
InChIKey: RDJGLLICXDHJDY-UHFFFAOYSA-N
Notes
- A propionic acid derivative that is used as a non-steroidal anti-inflammatory agent.
- An anti-inflammatory analgesic and antipyretic highly bound to plasma proteins. It is pharmacologically similar to ASPIRIN, but causes less gastrointestinal bleeding.
Molecular Formula
- C15-H14-O3
Molecular Weight
- 242.2726
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Analgesics
- Analgesics, Non-Narcotic
- Anti-Inflammatory Agents
- Anti-Inflammatory Agents, Non-Steroidal
- Antirheumatic Agents
- Cyclooxygenase Inhibitors
- Enzyme Inhibitors
- Peripheral Nervous System Agents
- Sensory System Agents
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Names and Synonyms
Name of Substance
- Fenoprofen
- Fenoprofen [USAN:INN:BAN]
MeSH Heading
- Fenoprofen
Synonyms
- (+-)-2-(3-Phenoxyphenyl)propionic acid
- (+-)-m-Phenoxyhydratropic acid
- BRN 2118687
- EINECS 249-770-1
- EINECS 250-850-3
- Fenoprofene
- Fenoprofene [INN-French]
- Fenoprofeno
- Fenoprofeno [INN-Spanish]
- Fenoprofenum
- Fenoprofenum [INN-Latin]
- HSDB 3328
- Lilly 53858
- NSC 757813
- UNII-RA33EAC7KY
Systematic Names
- 2-(3-Phenoxyphenyl)propionic acid
- Benzeneacetic acid, alpha-methyl-3-phenoxy-, (+-)-
Registry Numbers
CAS Registry Number
- 29679-58-1
FDA UNII
- RA33EAC7KY
Other Registry Number
- 31879-05-7
System Generated Number
- 0029679581
Structure Descriptors
InChI
InChI=1S/C15H14O3/c1-11(15(16)17)12-6-5-9-14(10-12)18-13-7-3-2-4-8-13/h2-11H,1H3,(H,16,17)InChIKey
RDJGLLICXDHJDY-UHFFFAOYSA-NSmiles
CC(C(=O)Toxicity
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| human | TDLo | oral | 4286ug/kg (4.286mg/kg) | ENDOCRINE: EVIDENCE OF THYROID HYPERFUNCTION | British Medical Journal. Vol. 292, Pg. 1560, 1986. |
| mouse | LD50 | oral | 1400mg/kg (1400mg/kg) | United States Patent Document. Vol. #3985779, | |
| rat | LD | oral | > 200mg/kg (200mg/kg) | GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH | Toxicology and Applied Pharmacology. Vol. 52, Pg. 454, 1980. |
| women | TDLo | oral | 1092mg/kg/13W (1092mg/kg) | KIDNEY, URETER, AND BLADDER: INTERSTITIAL NEPHRITIS KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" KIDNEY, URETER, AND BLADDER: OTHER CHANGES | Mayo Clinic Proceedings. Vol. 55, Pg. 103, 1980. |
| women | TDLo | oral | 9386mg/kg/1Y- (9386mg/kg) | KIDNEY, URETER, AND BLADDER: INTERSTITIAL NEPHRITIS | New England Journal of Medicine. Vol. 301, Pg. 1271, 1979. |
Physical Properties
| Physical Property | Value | Units | Temp (deg C) | Source |
|---|---|---|---|---|
| Melting Point | < 25 | deg C | EXP | |
| pKa Dissociation Constant | 7.3 | (none) | EXP | |
| log P (octanol-water) | 3.900 | (none) | EST | |
| Atmospheric OH Rate Constant | 1.87E-11 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.