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Substance Name: Levofloxacin [USAN:INN:JAN]
RN: 100986-85-4
UNII: RIX4E89Y14
InChIKey: GSDSWSVVBLHKDQ-JTQLQIEISA-N
Note
- A synthetic fluoroquinolone (FLUOROQUINOLONES) antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION./Ofloxacin/
Molecular Formula
- C18-H20-F-N3-O4
Molecular Weight
- 361.371
Classification Codes
- Anti-Infective Agents, Urinary
- Antiviral (COVID-19)
- Drug / Therapeutic Agent
- Reproductive Effect
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Names and Synonyms
Name of Substance
- Levofloxacin
- Levofloxacin [USAN:INN:JAN]
Synonyms
- (-)-Ofloxacin
- (S)-(-)-Ofloxacin
- (S)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid
- (S)-Ofloxacin
- CCRIS 4074
- Cravit
- DR3355
- Elequine
- HR 355
- HSDB 8028
- Iquix
- Levaquin
- Levaquin in dextrose 5% in plastic container
- Levofloxacin
- Levofloxacine
- Levofloxacine [INN-French]
- Levofloxacino
- Levofloxacino [INN-Spanish]
- Levofloxacinum
- Levofloxacinum [INN-Latin]
- Loxof
- MP 376
- MP-376
- Ofloxacin S-(-)-form
- Oftaquix
- Quixin
- RWJ 25213-097
- Tavanic
- Unibiotic
- UNII-RIX4E89Y14
- Venaxan
Systematic Names
- (-)-(S)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid
- 7H-Pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid, 2,3-dihydro-9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-, (S)-
- Levofloxacin
Registry Numbers
CAS Registry Number
- 100986-85-4
FDA UNII
- RIX4E89Y14
System Generated Number
- 0100986854
Structure Descriptors
InChI
InChI=1S/C18H20FN3O4/c1-10-9-26-17-14-11(16(23)12(18(24)25)8-22(10)14)7-13(19)15(17)21-5-3-20(2)4-6-21/h7-8,10H,3-6,9H2,1-2H3,(H,24,25)/t10-/m0/s1InChIKey
GSDSWSVVBLHKDQ-JTQLQIEISA-NSmiles
C[C@H]1COc2c(N3CCN(C)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
monkey | LD50 | oral | > 250mg/kg (250mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Arzneimittel-Forschung. Drug Research. Vol. 42, Pg. 365, 1992. |
mouse | LD50 | oral | 1803mg/kg (1803mg/kg) | SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Arzneimittel-Forschung. Drug Research. Vol. 42, Pg. 365, 1992. |
rat | LD50 | oral | 1478mg/kg (1478mg/kg) | SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Arzneimittel-Forschung. Drug Research. Vol. 42, Pg. 365, 1992. |
women | TDLo | oral | 122mg/kg/10D- (122mg/kg) | MUSCULOSKELETAL: OTHER CHANGES | Annals of Pharmacotherpy. Vol. 33, Pg. 792, 1999. |