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Substance Name: Tioconazole [USAN:USP:INN:BAN:JAN]
RN: 65899-73-2
UNII: S57Y5X1117
InChIKey: QXHHHPZILQDDPS-UHFFFAOYSA-N

Molecular Formula

  • C16-H13-Cl3-N2-O-S

Molecular Weight

  • 387.7167
 

Classification Codes

  • 14-alpha Demethylase Inhibitors
  • Anti-Infective Agents
  • Antifungal
  • Antifungal Agents
  • Cytochrome P-450 Enzyme Inhibitors
  • Enzyme Inhibitors
  • Hormone Antagonists
  • Metabolic Side Effects of Drugs and Substances
  • Reproductive Effect
  • Steroid Synthesis Inhibitors
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Names and Synonyms

Name of Substance

  • Tioconazole
  • Tioconazole [USAN:USP:INN:BAN:JAN]

Synonyms

  • (+-)-1-(2,4-Dichloro-beta-((2-chloro-3-ethenyl)oxy)phenethyl)imidazole
  • (+-)-Tioconazole
  • 1-(2,4-Dichloro-(beta-(2-chloro-3-thenyl)oxy)phenethyl)imidazole
  • 1-(2,4-Dichloro-beta-((2-chloro-3-thenyl)-oxy)phenethyl)imidazole
  • 1H-Imidazole, 1-(2-((2-chloro-3-thienyl)methoxy)-2-(2,4-dichlorophenyl)ethyl)-
  • 5-23-04-00324 (Beilstein Handbook Reference)
  • BRN 0573867
  • EINECS 265-973-8
  • Fungibacid
  • Gyno-Trosyd
  • New Straitus
  • NSC 759169
  • Tioconazol
  • Tioconazol [INN-Spanish]
  • Tioconazole
  • Tioconazolum
  • Tioconazolum [INN-Latin]
  • Trosyd
  • Trosyl
  • TZ-3
  • UK 20349
  • UK-20,349
  • UNII-S57Y5X1117
  • Vagistat
  • Vagistat-1
  • Zoniden

Systematic Names

  • 1H-Imidazole, 1-(2-((2-chloro-3-thienyl)methoxy)-2-(2,4-dichlorophenyl)ethyl)-
  • Tioconazole

Registry Numbers

CAS Registry Number

  • 65899-73-2

FDA UNII

  • S57Y5X1117

Other Registry Number

  • 144025-07-0

System Generated Number

  • 0065899732

Structure Descriptors

InChI

InChI=1S/C16H13Cl3N2OS/c17-12-1-2-13(14(18)7-12)15(8-21-5-4-20-10-21)22-9-11-3-6-23-16(11)19/h1-7,10,15H,8-9H2

InChIKey

QXHHHPZILQDDPS-UHFFFAOYSA-N

Smiles

Clc1ccc(C(Cn2ccnc2)OCc3ccsc3Cl)c(Cl)c1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 508mg/kg (508mg/kg)   Yakkyoku. Pharmacy. Vol. 35, Pg. 1623, 1984.
mouse LD50 intravenous 188mg/kg (188mg/kg)   British UK Patent Application. Vol. #2067993,
mouse LD50 oral 1870mg/kg (1870mg/kg)   Yakkyoku. Pharmacy. Vol. 35, Pg. 1623, 1984.
mouse LD50 subcutaneous > 10gm/kg (10000mg/kg)   Yakkyoku. Pharmacy. Vol. 35, Pg. 1623, 1984.
rat LD50 intraperitoneal 730mg/kg (730mg/kg)   Yakkyoku. Pharmacy. Vol. 35, Pg. 1623, 1984.
rat LD50 oral 770mg/kg (770mg/kg)   Yakkyoku. Pharmacy. Vol. 35, Pg. 1623, 1984.
rat LD50 subcutaneous > 10gm/kg (10000mg/kg)   Yakkyoku. Pharmacy. Vol. 35, Pg. 1623, 1984.