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Substance Name: Gentamicin [INN:BAN]
RN: 1403-66-3
UNII: T6Z9V48IKG
InChIKey: CEAZRRDELHUEMR-UHFFFAOYSA-N
Note
- A complex of three different closely related aminoglycoside sulfates, Gentamicins C1, C2, and C1(subA), obtained from Micromonospora purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit protein synthesis ( GENETIC TRANSLATION).
Molecular Weight
- 477.599
- All
- Classifications
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- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Anti-Bacterial Agents
- Anti-Infective Agents
- Drug / Therapeutic Agent
- Enzyme Inhibitors
- Human Data
- Mutation Data
- Natural Product
- Protein Synthesis Inhibitors
- Reproductive Effect
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Names and Synonyms
Results Name
- Gentamicin [INN:BAN]
Name of Substance
- Gentamicin [INN:BAN]
- Gentamicin [INN]
- Gentamycin
MeSH Heading
- Gentamicins
Synonyms
- Centicin
- Cidomycin
- EINECS 215-765-8
- Garamycin
- Garasol
- Gentacycol
- Gentalline
- Gentamicin
- Gentamicina
- Gentamicina [INN-Spanish]
- Gentamicine
- Gentamicine [INN-French]
- Gentamicinum
- Gentamicinum [INN-Latin]
- Gentamycin
- Gentamycin-creme
- Gentamycin-creme [German]
- Gentamycins
- Gentamycinum
- Gentavet
- Gentocin
- HSDB 3087
- Lyramycin
- Oksitselanim
- Refobacin
- Refobacin TM
- Septigen
- UNII-T6Z9V48IKG
- Uromycine
Systematic Name
- Gentamicin
Registry Numbers
CAS Registry Number
- 1403-66-3
FDA UNII
- T6Z9V48IKG
System Generated Number
- 0001403663
Structure Descriptors
InChI
InChI=1S/C21H43N5O7/c1-9(25-3)13-6-5-10(22)19(31-13)32-16-11(23)7-12(24)17(14(16)27)33-20-15(28)18(26-4)21(2,29)8-30-20/h9-20,25-29H,5-8,22-24H2,1-4H3InChIKey
CEAZRRDELHUEMR-UHFFFAOYSA-NSmiles
CNC(C)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
cat | LD50 | intramuscular | 430mg/kg (430mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: ATAXIA | Arzneimittel-Forschung. Drug Research. Vol. 16, Pg. 11, 1966. |
cat | LD50 | intraperitoneal | 304mg/kg (304mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: ATAXIA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Arzneimittel-Forschung. Drug Research. Vol. 16, Pg. 11, 1966. |
cat | LD50 | intravenous | 88mg/kg (88mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: ATAXIA | Arzneimittel-Forschung. Drug Research. Vol. 16, Pg. 11, 1966. |
dog | LD50 | intramuscular | 750mg/kg (750mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: ATAXIA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Arzneimittel-Forschung. Drug Research. Vol. 16, Pg. 11, 1966. |
dog | LD50 | intraperitoneal | 710mg/kg (710mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Arzneimittel-Forschung. Drug Research. Vol. 16, Pg. 11, 1966. |
dog | LD50 | intravenous | 184mg/kg (184mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Arzneimittel-Forschung. Drug Research. Vol. 16, Pg. 11, 1966. |
guinea pig | LD50 | intraperitoneal | 530mg/kg (530mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: ATAXIA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Arzneimittel-Forschung. Drug Research. Vol. 16, Pg. 11, 1966. |
guinea pig | LD50 | subcutaneous | 740mg/kg (740mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Arzneimittel-Forschung. Drug Research. Vol. 16, Pg. 11, 1966. |
human | TDLo | intravenous | 2mg/kg (2mg/kg) | KIDNEY, URETER, AND BLADDER: OTHER CHANGES | New England Journal of Medicine. Vol. 303, Pg. 1002, 1980. |
human | TDLo | intravenous | 23mg/kg/1Y-I (23mg/kg) | PERIPHERAL NERVE AND SENSATION: SENSORY CHANGE INVOLVING TRIGEMINAL NERVE | Archives of Internal Medicine. Vol. 138, Pg. 1621, 1978. |
infant | TDLo | intramuscular | 20mg/kg (20mg/kg) | KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" | Pediatrics. Vol. 77, Pg. 848, 1986. |
man | TDLo | intramuscular | 8mg/kg/2W-I (8mg/kg) | SENSE ORGANS AND SPECIAL SENSES: HEMORRHAGE: EYE SENSE ORGANS AND SPECIAL SENSES: VISUAL FIELD CHANGES: EYE SKIN AND APPENDAGES (SKIN): HAIR: OTHER | JAMA, Journal of the American Medical Association. Vol. 211, Pg. 123, 1970. |
mouse | LD50 | intramuscular | 167mg/kg (167mg/kg) | BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) | Japanese Journal of Antibiotics. Vol. 35, Pg. 461, 1982. |
mouse | LD50 | intraperitoneal | 235mg/kg (235mg/kg) | Journal of International Medical Research. Vol. 2, Pg. 100, 1974. | |
mouse | LD50 | intravenous | 43500ug/kg (43.5mg/kg) | Antibiotiki. Vol. 21, Pg. 532, 1976. | |
mouse | LD50 | oral | 10gm/kg (10000mg/kg) | BEHAVIORAL: ATAXIA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) | Japanese Journal of Antibiotics. Vol. 30, Pg. 386, 1977. |
mouse | LD50 | subcutaneous | 274mg/kg (274mg/kg) | Toxicology and Applied Pharmacology. Vol. 25, Pg. 398, 1973. | |
rabbit | LD50 | intramuscular | 780mg/kg (780mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Arzneimittel-Forschung. Drug Research. Vol. 16, Pg. 11, 1966. |
rabbit | LD50 | intraperitoneal | 1350mg/kg (1350mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: ATAXIA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Arzneimittel-Forschung. Drug Research. Vol. 16, Pg. 11, 1966. |
rabbit | LD50 | intravenous | 81mg/kg (81mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Arzneimittel-Forschung. Drug Research. Vol. 16, Pg. 11, 1966. |
rabbit | LD50 | subcutaneous | 1230mg/kg (1230mg/kg) | BEHAVIORAL: ATAXIA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Arzneimittel-Forschung. Drug Research. Vol. 16, Pg. 11, 1966. |
rat | LD50 | intramuscular | 463mg/kg (463mg/kg) | Japanese Journal of Antibiotics. Vol. 35, Pg. 461, 1982. | |
rat | LD50 | intraperitoneal | 735mg/kg (735mg/kg) | Journal of International Medical Research. Vol. 2, Pg. 100, 1974. | |
rat | LD50 | intravenous | 70mg/kg (70mg/kg) | Journal of International Medical Research. Vol. 2, Pg. 100, 1974. | |
rat | LD50 | oral | 6600mg/kg (6600mg/kg) | BEHAVIORAL: TREMOR GASTROINTESTINAL: OTHER CHANGES BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Archives des Maladies Professionnelles de Medecine du Travail et de Securite Sociale. Vol. 39, Pg. 259, 1978. |
rat | LD50 | subcutaneous | 710mg/kg (710mg/kg) | Journal of International Medical Research. Vol. 2, Pg. 100, 1974. | |
women | TDLo | intravenous | 8200ug/kg/12D (8.2mg/kg) | SENSE ORGANS AND SPECIAL SENSES: CHANGES IN VESTIBULAR FUNCTIONS: EAR BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" | Acta Pathologica et Microbiologica Scandinavica, Section B: Microbiology and Immunology. Vol. 81(Suppl, |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 105 | deg C | EXP | |
log P (octanol-water) | -1.880 | (none) | EST | |
Atmospheric OH Rate Constant | 4.05E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.